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. 2023 Jun 8;18(6):e0286395.
doi: 10.1371/journal.pone.0286395. eCollection 2023.

Correlation of bone density measured on CT chest with the severity of COVID-19 infection: A retrospective study

Noha Bakhsh  1 , Mai Banjar  2 , Mukhtiar Baig  3
Affiliations

Correlation of bone density measured on CT chest with the severity of COVID-19 infection: A retrospective study

Noha Bakhsh et al. PLoS One. .

Abstract

Purpose: This retrospective study investigated the correlation between bone mineral density (BMD) and COVID-19 severity among COVID-19 patients who underwent chest computed tomography (CT) scans.

Methods: This study was carried out at the King Abdullah Medical Complex in Jeddah, Saudi Arabia, one of the largest COVID-19 centers in the western province. All adult COVID-19 patients who had a chest CT between January 2020 and April 2022 were included in the study. The pulmonary severity scores (PSS) and vertebral BMD measurements were obtained from the patient's CT chest. Data from the patients' electronic records were collected.

Results: The average patient age was 56.4 years, and most (73.5%) patients were men. Diabetes (n = 66, 48.5%), hypertension (n = 56, 41.2%), and coronary artery disease (n = 17, 12.5%) were the most prevalent comorbidities. Approximately two-thirds of hospitalized patients required ICU admission (64%), and one-third died (30%). The average length of stay in the hospital was 28.4 days. The mean CT pneumonia severity score (PSS) was 10.6 at the time of admission. Patients with lower vertebral BMD (< = 100) numbered 12 (8.8%), while those with higher vertebral BMD (>100) numbered 124 (91.2%). Only 46 out of the total survived patients (n = 95) were admitted to the ICU versus all deceased (P<0.01). The logistic regression analysis revealed that an elevated PSS upon admission resulted in a reduced chance of survival. Age, gender, and BMD did not predict survival chances.

Conclusion: The BMD had no prognostic advantage, and the PSS was the significant factor that could have predicted the outcome.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. The flow chart of the inclusion and exclusion criteria.
See this image and copyright information in PMC

References

    1. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al.. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199–207. doi: 10.1056/NEJMoa2001316 - DOI - PMC - PubMed
    1. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al.. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506. - PMC - PubMed
    1. Tang J. COVID-19 Pandemic and Osteoporosis in Elderly Patients. Aging Dis. 2022;13(4):960–9. doi: 10.14336/AD.2021.1201 - DOI - PMC - PubMed
    1. Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, et al.. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017–32. doi: 10.1038/s41591-020-0968-3 - DOI - PMC - PubMed
    1. Hasan LK, Deadwiler B, Haratian A, Bolia IK, Weber AE, Petrigliano FA. Effects of COVID-19 on the Musculoskeletal System: Clinician’s Guide. Orthop Res Rev. 2021; 13:141–50. doi: 10.2147/ORR.S321884 - DOI - PMC - PubMed