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. 2023 Oct;62(4):531-539.
doi: 10.1002/uog.26284.

Prediction model for hypertension in first decade after pre-eclampsia in initially normotensive women

M C E Hooijschuur  1   2 , E B N J Janssen  1   3   4 , E G Mulder  1 , A A Kroon  3   5 , J M J Meijers  1 , J J Brugts  6 , B C T Van Bussel  7 , S M J Van Kuijk  8 , M E A Spaanderman  1 , C Ghossein-Doha  1   3   4
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Free article

Prediction model for hypertension in first decade after pre-eclampsia in initially normotensive women

M C E Hooijschuur et al. Ultrasound Obstet Gynecol. 2023 Oct.
Free article

Abstract

Objective: To develop a prediction model for the development of hypertension in the decade following pre-eclampsia in women who were normotensive shortly after pregnancy.

Methods: This was a longitudinal cohort study of formerly pre-eclamptic women attending a university hospital in The Netherlands between 1996 and 2019. We developed a prediction model for incident hypertension using multivariable logistic regression analysis. The model was validated internally using bootstrapping techniques.

Results: Of 259 women, 185 (71%) were normotensive at the first cardiovascular assessment, at a median of 10 (interquartile range (IQR), 6-24) months after a pre-eclamptic pregnancy, of whom 49 (26%) had developed hypertension by the second visit, at a median of 11 (IQR, 6-14) years postpartum. The prediction model, based on birth-weight centile, mean arterial pressure, total cholesterol, left ventricular mass index and left ventricular ejection fraction, had good-to-excellent discriminative ability, with an area under the receiver-operating-characteristics curve (AUC) of 0.82 (95% CI, 0.75-0.89) and an optimism-corrected AUC of 0.80. The sensitivity and specificity of our model to predict hypertension were 98% and 34%, respectively, and positive and negative predictive values were 35% and 98%, respectively.

Conclusions: Based on five variables, we developed a good-to-excellent predictive tool to identify incident hypertension following pre-eclampsia in women who were normotensive shortly after pregnancy. After external validation, this model could have considerable clinical utility in tackling the cardiovascular legacy of pre-eclampsia. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

Keywords: cardiovascular disease; cardiovascular risk; hypertension; pre-eclampsia.

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References

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