Remyelination by preexisting oligodendrocytes: Glass half full or half empty?
- PMID: 37290399
- DOI: 10.1016/j.neuron.2023.05.001
Remyelination by preexisting oligodendrocytes: Glass half full or half empty?
Abstract
The central dogma in remyelination states that the primary cellular source for myelin repair are the oligodendrocyte precursor cells. In this issue of Neuron, Mezydlo et al.1 highlight the potential of preexisting oligodendrocytes as an alternative, albeit minor, source for new myelin, with implications for demyelinating disorder research and therapies.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex.Neuron. 2023 Jun 7;111(11):1748-1759.e8. doi: 10.1016/j.neuron.2023.03.031. Epub 2023 Apr 17. Neuron. 2023. PMID: 37071991
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