MLKC reports personal fees from Astellas, Janssen, Bayer, Pfizer, BeiGene, MSD, Varian, IQVIA, Telix Pharmaceuticals; personal fees and non-financial support from AstraZeneca; non-financial support from Decipher Biosciences and MedLever; consulting fees from immunoSCAPE; is a co-inventor of the patent of a High Sensitivity Lateral Flow Immunoassay For Detection of Analyte in Sample (10202107837T), Singapore; and serves on the Board of Directors of Digital Life Line that owns the licensing agreement of the patent, outside the submitted work. MLKC is supported by the National Medical Research Council Singapore Clinician Scientist Award (NMRC/CSAINV20nov-0021), the Duke-NUS Oncology Academic Program Goh Foundation Proton Research Programme, NCCS Cancer Fund, and the Kua Hong Pak Head and Neck Cancer Research Programme. All other authors declare no competing interests.