Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct 1;49(10):1068-1070.
doi: 10.1097/j.jcrs.0000000000001237.

ASCRS clinical advisory on intracameral moxifloxacin injection for infection prophylaxis

William G Myers  1 , David F Chang, Neal H Shorstein, Francis S Mah, Nick Mamalis, Kevin M Miller; ASCRS Cataract Clinical Committee
Affiliations

ASCRS clinical advisory on intracameral moxifloxacin injection for infection prophylaxis

William G Myers et al. J Cataract Refract Surg. .

Abstract

Moxifloxacin solution is frequently injected at the conclusion of cataract surgery for endophthalmitis prophylaxis. 2 different concentrations are most commonly available in the United States for intracameral (IC) use: 0.5% (5 mg/mL) and 0.1% (1 mg/mL). The recommended volume to be injected is different for the 2 concentrations, and incorrect dosing can increase the risk of toxic anterior segment syndrome or endophthalmitis. In addition, the U.S. Food and Drug Administration recently published an alert regarding potential adverse events associated with intraocular compounded moxifloxacin. This clinical advisory reviews the optimal dosing of IC moxifloxacin based on current evidence.

PubMed Disclaimer

Conflict of interest statement

Disclosures: W.G. Myers is a consultant and Medical Director at Leiters and a consultant and minority owner of Zion Therapeutics. None of the other authors has any relevant financial conflict of interests to report.

References

    1. Available at: https://www.fda.gov/drugs/drug-safety-and-availability/fda-alerts-health... . Accessed June 14, 2023.
    1. Miller KM, Oetting TA, Tweeten JP, Carter K, Lee BS, Lin S, Nanji AA, Shorstein NH, Musch DC; American Academy of Ophthalmology Preferred Practice Pattern Cataract/Anterior Segment Panel. Cataract in the adult eye preferred practice pattern. Ophthalmology 2022;129:P1–P126
    1. Chang DF, Rhee DJ. Antibiotic prophylaxis of postoperative endophthalmitis following cataract surgery: results of the 2021 ASCRS member survey. J Cataract Refract Surg 2022;48:3–7
    1. Chang DF, Braga Mele R, Mamalis N, Masket S, Miller KM, Nichamin LD, Packard RB, Packer M. Prophylaxis of postoperative endophthalmitis following cataract surgery: results of the 2007 ASCRS Member Survey. J Cataract Refract Surg 2007;33:1988–1989
    1. Chang DF, Braga-Mele R, Henderson BA, Mamalis N, Vasavada A. Antibiotic prophylaxis of postoperative endophthalmitis following cataract surgery: results of the 2014 ASCRS Member Survey. J Cataract Refract Surg 2015;41:1300–1305

MeSH terms

LinkOut - more resources