The pyrimidinosome is cancer's Achilles' heel
- PMID: 37291266
- DOI: 10.1038/s41556-023-01159-z
The pyrimidinosome is cancer's Achilles' heel
Comment on
-
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.Nat Cell Biol. 2023 Jun;25(6):836-847. doi: 10.1038/s41556-023-01146-4. Epub 2023 Jun 8. Nat Cell Biol. 2023. PMID: 37291265
Similar articles
-
Cancer's Achilles' Heel: Apoptosis and Necroptosis to the Rescue.Int J Mol Sci. 2016 Dec 23;18(1):23. doi: 10.3390/ijms18010023. Int J Mol Sci. 2016. PMID: 28025559 Free PMC article. Review.
-
Telomeres: has cancer's Achilles' heel been exposed?Nat Med. 1999 Oct;5(10):1129-30. doi: 10.1038/13451. Nat Med. 1999. PMID: 10502812 No abstract available.
-
Cancer's new Achilles' heel?Oncotarget. 2017 Aug 5;8(34):55774-55775. doi: 10.18632/oncotarget.19954. eCollection 2017 Aug 22. Oncotarget. 2017. PMID: 28915551 Free PMC article. No abstract available.
-
The Achilles' Heel of Pancreatic Cancer: Targeting pancreatic cancer's unique immunologic characteristics and metabolic dependencies in clinical trials.J Pancreatol. 2020 Sep;3(3):121-131. doi: 10.1097/JP9.0000000000000052. J Pancreatol. 2020. PMID: 33133736 Free PMC article. No abstract available.
-
Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer's Achilles' Heel.Cancers (Basel). 2021 Mar 19;13(6):1392. doi: 10.3390/cancers13061392. Cancers (Basel). 2021. PMID: 33808562 Free PMC article. Review.
Cited by
-
Genome-wide RNAi screening in C. elegans reveals OXPHOS and pyrimidine synthesis pathways as PKA regulators.Commun Biol. 2025 Aug 26;8(1):1280. doi: 10.1038/s42003-025-08718-0. Commun Biol. 2025. PMID: 40855216 Free PMC article.
-
Fluorescent Heterocyclic Compound-Loaded Bi2Se3-Polysorbate Nanoparticles for Targeted Therapy in Non-Small Cell Lung Cancer.J Fluoresc. 2025 Jan 8. doi: 10.1007/s10895-024-04104-x. Online ahead of print. J Fluoresc. 2025. PMID: 39777623
References
-
- Yang, C. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-023-01146-4 (2023). - DOI - PubMed
-
- Jones, M. E. & Lipmann, F. J. Biol. Chem. 217, 361–371 (1955). - DOI
-
- Rabinowitz, J. C. & Lipmann, F. J. Biol. Chem. 216, 727–736 (1955). - DOI
-
- Weinberg, J. B. & Jones, M. E. J. Biol. Chem. 239, 2278–2286 (1964).
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical