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. 2023 Aug;27(8):4727-4733.
doi: 10.1007/s00784-023-05100-4. Epub 2023 Jun 8.

Associations between vitamin D levels and periodontal attachment loss

Xiaoyun Liu  1 , Bichong Dai  1 , Yuanyuan Chuai  1 , Menglin Hu  1 , Hengguo Zhang  2   3
Affiliations

Associations between vitamin D levels and periodontal attachment loss

Xiaoyun Liu et al. Clin Oral Investig. 2023 Aug.

Abstract

Objectives: Periodontitis is accompanied by attachment loss and alveolar bone resorption. Vitamin D (VD) deficiency was closely associated with bone loss or osteoporosis. The study aims to investigate the potential relationship between different VD levels and severe periodontal attachment loss in American adults.

Methods: A cross-sectional analysis was conducted including 5749 participants in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2014. The association of periodontal attachment loss progression with total VD, vitamin D3 (VD3), and vitamin D2 (VD2) levels was assessed using multivariable linear regression models, hierarchical regression, fitted smoothing curves, and generalized additive models.

Results: Based on the indicators of 5749 subjects, we found that severe attachment loss tended to occur in the elderly or males and was accompanied by less total VD levels, or VD3 levels, as well as a lower poverty-income ratio (PIR). Total VD (below the inflection point: 111 nmol/L) or VD3 were negatively associated with the progression of attachment loss in each multivariable regression model. In threshold analysis, VD3 is linearly correlated with the progression of attachment loss (β = - 0.0183, 95% CI: - 0.0230 to - 0.0136). The relationship between VD2 and attachment loss progression was an S-shaped curve (inflection point: 5.07 nmol/L).

Conclusion: Increasing total VD (below 111 nmol/L) and VD3 levels may be beneficial to periodontal health. VD2 levels above 5.07 nmol/L were a risk factor for severe periodontitis.

Clinical relevance: The present study reports that different vitamin D levels may serve as different associations with periodontal attachment loss progression.

Keywords: Attachment loss; Periodontitis; Total vitamin D; Vitamin D2; Vitamin D3.

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References

    1. Nazir M, Al-Ansari A, Al-Khalifa K, Alhareky M, Gaffar B, Almas K (2020) Global prevalence of periodontal disease and lack of its surveillance. TheScientificWorldJOURNAL 2020:2146160. https://doi.org/10.1155/2020/2146160 - DOI - PubMed - PMC
    1. Rodrigues Amorim Adegboye A, Dias Santana D, Teixeira Dos Santos PP, Guedes Cocate P, Benaim C, Trindade de Castro MB, Maia Schlüssel M, Kac G, Lilienthal Heitmann B (2021) Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile. Nutrients 13(3):783. https://doi.org/10.3390/nu13030783 - DOI - PubMed - PMC
    1. Kwon T, Lamster IB, Levin L (2021) Current concepts in the management of periodontitis. Int Dent J 71(6):462–476. https://doi.org/10.1111/idj.12630 - DOI - PubMed - PMC
    1. Herrera D, Sanz M, Kebschull M, Jepsen S, Sculean A, Berglundh T, Papapanou PN, Chapple I, Tonetti MS, EFP Workshop Participants and Methodological Consultant (2022) Treatment of stage IV periodontitis: the EFP S3 level clinical practice guideline. J Clin Periodontol 49(Suppl 24):4–71. https://doi.org/10.1111/jcpe.13639 - DOI - PubMed
    1. Tak IH, Shin MH, Kweon SS, Nam HS, Cauley JA, Kim OJ, Kim YJ, Chung HJ, Kim OS (2014) The association between periodontal disease, tooth loss and bone mineral density in a Korean population. J Clin Periodontol 41(12):1139–1144. https://doi.org/10.1111/jcpe.12309 - DOI - PubMed

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