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Review
. 2023 Mar;14(3):227-249.
doi: 10.4155/tde-2023-0001. Epub 2023 Jun 9.

Nanomaterials: an intra-periodontal pocket drug-delivery system for periodontitis

Nethish R Kumaar  1 , Sreeja C Nair  1
Affiliations
Review

Nanomaterials: an intra-periodontal pocket drug-delivery system for periodontitis

Nethish R Kumaar et al. Ther Deliv. 2023 Mar.

Abstract

Periodontitis is a microbiological condition that affects the tissues supporting the teeth. The fundamental to effective periodontal therapy is choosing the suitable antimicrobial and anti-inflammatory agent, together with the proper route of drug administration and delivery system. Intra-periodontal pocket approach with nano drug-delivery systems (NDDS) such as polymeric nanoparticles, gold nanoparticles, silica nanoparticles, magnetic nanoparticles, liposomes, polymersomes, exosomes, nano micelles, niosome, solid lipid nanoparticles, nano lipid carriers, nanocomposites, nanogels, nanofibers, scaffolds, dendrimers, quantum dots, etc., will be appropriate route of drug administration and delivery system. This NDDS delivers the drugs at the site of infection to inhibit growth and promote tissue regeneration. The present review focused on providing comprehensive information on the NDDS for periodontitis, which enhanced therapeutic outcomes via intra-periodontal pocket delivery.

Keywords: anti-inflammatory; antimicrobial; intra-periodontal pocket administration; nano drug-delivery system; periodontitis.

Plain language summary

Periodontitis is a problem that can make your teeth fall out. It happens when the tissues that hold your teeth start to break down. Scientists have found a way to help treat it by using tiny things called ‘nano drug-delivery systems’ or NDDS. These NDDS carry medicine to the infected area and stop the germs from growing. They can also help the tissue around your teeth to heal. Some examples of NDDS are liposomes, polymersomes, exosomes, nanomicelles, and more. Regular treatment with antibiotics may not work as well as NDDS. Using NDDS can make a big difference in how well your teeth and gums heal. In the future, scientists hope to use NDDS to prevent the problem from coming back. This new way of treating periodontitis could be a big help for people with this problem.

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