Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar-Apr;27(2):118-126.
doi: 10.4103/ijem.ijem_451_22. Epub 2023 Apr 14.

Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia

Isaac J Bage  1 , Sadishkumar Kamalanathan  1 , Sandhiya Selvarajan  2 , Jayaprakash Sahoo  1 , Jayanthi Mathaiyan  3 , Dukhabandhu Naik  1
Affiliations

Peroxisome Proliferator-Activated Receptor α and γ Gene Polymorphisms among South Indian Patients with Diabetic Dyslipidaemia

Isaac J Bage et al. Indian J Endocrinol Metab. 2023 Mar-Apr.

Abstract

Background: Peroxisome proliferator-activated receptors (PPAR) α and γ genes play an important role in dyslipidaemia of T2DM.

Aims: To estimate the frequency distribution of PPAR α and γ gene polymorphisms in South Indian T2DM patients with dyslipidaemia compared to healthy controls. Normative frequencies of SNPs were established and compared with data for 1000 genome populations.

Methods: Eligible 382 cases and 336 age and sex-matched controls were enrolled. Six SNPs in PPARα [rs1800206 C>G (Leu162Val), rs4253778 G>C, rs135542 T>C] and PPARγ [rs3856806 (C>T), rs10865710 (C>G), rs1805192 C>G (Pro12Ala)] genes were selected for genotyping.

Results: The allele and gene frequencies did not significantly differ between the diabetic dyslipidaemia cases and healthy controls. However, they were significantly different from that of 1000 genome populations except for rs1800206 C>G (Leu162Val) and rs1805192 C>G (Pro12Ala).

Conclusion: The studied polymorphisms in PPARα and PPARγ genes are not associated with diabetic dyslipidaemia among South Indian patients.

Keywords: Diabetic dyslipidaemia; Minor allele frequency; PPARα/γ gene; Single-nucleotide polymorphisms.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

References

    1. Diabetes DOF. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33(Suppl 1):S62–9. - PMC - PubMed
    1. Saeedi P, Petersohn I, Salpea P, Malanda B, Karuranga S, Unwin N, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045:Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843. - PubMed
    1. Duval C, Müller M, Kersten S. PPARα and dyslipidemia. Biochim Biophys Acta-Mol Cell Biol Lipids. 2007;1771:961–71. - PubMed
    1. Pyper SR, Viswakarma N, Yu S, Reddy JK. PPARα:Energy combustion, hypolipidemia, inflammation and cancer. Nucl Recept Signal. 2010;8:e002. doi:10.1621/nrs.08002. - PMC - PubMed
    1. Lefebvre P, Chinetti G, Fruchart JC, Staels B, Issemann I, Green S, et al. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J Clin Invest. 2006;116:571–80. - PMC - PubMed