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Review
. 2023 May 24:11:1160577.
doi: 10.3389/fbioe.2023.1160577. eCollection 2023.

Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine

Nur Izzah Md Fadilah  1 , Shaima Maliha Riha  1 , Zawani Mazlan  1 , Adzim Poh Yuen Wen  2 , Looi Qi Hao  3 , Blessy Joseph  4 , Manira Maarof  1 , Sabu Thomas  5 , Antonella Motta  6 , Mh Busra Fauzi  1
Affiliations
Review

Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine

Nur Izzah Md Fadilah et al. Front Bioeng Biotechnol. .

Abstract

Skin tissue engineering possesses great promise in providing successful wound injury and tissue loss treatments that current methods cannot treat or achieve a satisfactory clinical outcome. A major field direction is exploring bioscaffolds with multifunctional properties to enhance biological performance and expedite complex skin tissue regeneration. Multifunctional bioscaffolds are three-dimensional (3D) constructs manufactured from natural and synthetic biomaterials using cutting-edge tissue fabrication techniques incorporated with cells, growth factors, secretomes, antibacterial compounds, and bioactive molecules. It offers a physical, chemical, and biological environment with a biomimetic framework to direct cells toward higher-order tissue regeneration during wound healing. Multifunctional bioscaffolds are a promising possibility for skin regeneration because of the variety of structures they provide and the capacity to customise the chemistry of their surfaces, which allows for the regulated distribution of bioactive chemicals or cells. Meanwhile, the current gap is through advanced fabrication techniques such as computational designing, electrospinning, and 3D bioprinting to fabricate multifunctional scaffolds with long-term safety. This review stipulates the wound healing processes used by commercially available engineered skin replacements (ESS), highlighting the demand for a multifunctional, and next-generation ESS replacement as the goals and significance study in tissue engineering and regenerative medicine (TERM). This work also scrutinise the use of multifunctional bioscaffolds in wound healing applications, demonstrating successful biological performance in the in vitro and in vivo animal models. Further, we also provided a comprehensive review in requiring new viewpoints and technological innovations for the clinical application of multifunctional bioscaffolds for wound healing that have been found in the literature in the last 5 years.

Keywords: biomaterials; multifunctional bioscaffolds; skin substitutes; skin tissue engineering; wound healing.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Three key elements in combining to form tissue engineered construct for tissue engineering and regenerative medicine.
FIGURE 2
FIGURE 2
Bioengineered skin substitute (graft) for wound healing application.
FIGURE 3
FIGURE 3
Type of biomaterials utilised for multifunctional scaffold manufacture.
FIGURE 4
FIGURE 4
Types of multifunctional bioscaffold for wound healing purposes.
See this image and copyright information in PMC

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