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Review
. 2023 May 24:14:1183542.
doi: 10.3389/fimmu.2023.1183542. eCollection 2023.

Regulatory role of the programmed cell death 1 signaling pathway in sepsis induced immunosuppression

Shubai Zhong  1 , Yuanqin Yin  2
Affiliations
Review

Regulatory role of the programmed cell death 1 signaling pathway in sepsis induced immunosuppression

Shubai Zhong et al. Front Immunol. .

Abstract

Sepsis is a multiple organ dysfunction syndrome caused by the host's immune response to infection, with extremely high incidence and mortality. Immunosuppression is an essential pathophysiological alteration that influences the clinical treatment and prognosis of sepsis. Recent studies have suggested that the programmed cell death 1 signaling pathway is involved in the formation of immunosuppression in sepsis. In this review, we systematically present the mechanisms of immune dysregulation in sepsis and elucidate the expression and regulatory effects of the programmed cell death 1 signaling pathway on immune cells associated with sepsis. We then specify current research developments and prospects for the application of the programmed cell death 1 signaling pathway in immunomodulatory therapy for sepsis. Several open questions and future research are discussed at the end.

Keywords: immunomodulation; immunosuppression; immunotherapy; programmed cell death 1; sepsis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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