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Case Reports
. 2023 May 26;9(6):e16618.
doi: 10.1016/j.heliyon.2023.e16618. eCollection 2023 Jun.

A case of localized paranasal sinusitis associated with Burkholderia cenocepacia ST 1880 in a cystic fibrosis patient

Olga Kondratenko  1 , Artem Lyamin  1 , Tatiana Savinova  2 , Yuliya Bocharova  2 , Elena Vasilyeva  1 , Igor Chebotar  2
Affiliations
Case Reports

A case of localized paranasal sinusitis associated with Burkholderia cenocepacia ST 1880 in a cystic fibrosis patient

Olga Kondratenko et al. Heliyon. .

Abstract

Burkholderia cepacia complex (Bcc) bacteria are considered to be very dangerous players in cystic fibrosis (CF) pathogenesis and are a criterion for negative prognosis in CF cases. In this report, a pediatric case of paranasal sinusitis caused by Burkholderia cenocepacia in a CF patient is described. This is an unusual case, since the paranasal sinuses were the only colonization locus of B. cenocepacia in this patient for 5 years (2015-2020). The lungs remained microbiologically clear with no clinical or radiological signs of pulmonary function decrease during this time period. The paranasal sinuses were sanitized by endoscopic sinus surgery on the left side (2020). Although having no local or systemic antibiotic treatment from the time of surgery to 2022, no B. cenocepacia were detected in the samples. The case shows the possibility of a prolonged remission of Bcc-associated paranasal sinusitis in the absence of systemic antibiotic therapy.

Keywords: Burkholderia; Cystic fibrosis; Sinusitis.

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Conflict of interest statement

The authors declare no conflicts.

Figures

Fig. 1
Fig. 1
Chronology of B. cenocepacia isolation in patient S. with cystic fibrosis, 2015–2022. Red asterisk, the time point when the patient was subjected to endoscopic hemisinusotomy. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Figure 1 Suppl.jpg
Figure 1 Suppl.jpg
See this image and copyright information in PMC

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