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. 2023 May 24:13:1164526.
doi: 10.3389/fcimb.2023.1164526. eCollection 2023.

Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon

Julia Dugardin  1 , Magalie Demar  2 , Nezha Hafsi  1 , Hakim Amroun  3 , Jean-Markens Aurelus  1 , Kinan Drak Alsibai  4 , André Ntoutoum  1 , Florin Santa  5 , Mathieu Nacher  6 , Nadia Sabbah  1   6
Affiliations

Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon

Julia Dugardin et al. Front Cell Infect Microbiol. .

Abstract

Background: Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus known to cause two major diseases: adult T-cell leukemia/lymphoma and a progressive neuromyelopathy-tropical spastic paraparesis. Many viruses may be involved in the pathogenesis of thyroiditis; however, few studies have focused on the role of HTLV-1. We aimed to investigate the association between HTLV-1 and biological thyroid dysfunction.

Methods: We included 357 patients with a positive HTLV-1 serology and thyroid-stimulating hormone assay data between 2012 and 2021 in a hospital in French Guiana; we compared the prevalence of hypothyroidism and hyperthyroidism in this group with that in an HTLV-1-negative control group (722 persons) matched for sex and age.

Results: The prevalence of hypothyroidism and hyperthyroidism in patients with HTLV-1 infection was significantly higher than that in the control group (11% versus 3.2% and 11.3% versus 2.3%, respectively; p < 0.001).

Conclusion: Our study shows, for the first time, the association between HTLV-1 and dysthyroidism in a large sample, suggesting that thyroid function exploration should be systematically implemented in this population as this may have an impact on therapeutic management.

Keywords: French Guiana; HTLV- 1; TSH (thyroid stimulating hormone); hyperthyroidism; hypothyroidism; thyroiditis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the HTLV-1 population.
Figure 2
Figure 2
Flowchart of the control population.
See this image and copyright information in PMC

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