T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Saori C Iwase^{1

2}, Paul T Edlefsen³, Lynnette Bhebhe⁴, Kesego Motsumi⁴, Sikhulile Moyo^{4

5}, Anna-Ursula Happel^{1

2}, Danica Shao³, Nicholas Mmasa⁶, Sara Schenkel⁷, Melanie A Gasper⁸, Melanie Dubois^{7

9}, Megan A Files¹⁰, Chetan Seshadri¹⁰, Fergal Duffy⁸, John Aitchison⁸, Mihai G Netea^{11

12}, Jennifer Jao^{4

13}, Donald W Cameron¹⁴, Clive M Gray^{1

2

15}, Heather B Jaspan^{1

2

8}, Kathleen M Powis^{4

5

16}

Affiliations

¹ Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
² Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
³ Vaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
⁴ Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
⁵ Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
⁶ Surgical Department, County Durham and Darlington NHS Trust, Darlington Memorial Hospital, Darlington, United Kingdom.
⁷ Division of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁸ Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
⁹ Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
¹⁰ Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
¹¹ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
¹² Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
¹³ Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹⁴ Divisions of Infectious Diseases and Respirology, University of Ottawa at the Ottawa Hospital, Ottawa, Canada.
¹⁵ Division of Molecular Biology and Human Genetics, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa.
¹⁶ Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.

PMID: 37293702
PMCID: PMC10573724
DOI: 10.1093/cid/ciad356

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Saori C Iwase et al. Clin Infect Dis. 2023.

. 2023 Oct 13;77(8):1133-1136.

doi: 10.1093/cid/ciad356.

Authors

Affiliations

¹ Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa.
² Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
³ Vaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
⁴ Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
⁵ Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
⁶ Surgical Department, County Durham and Darlington NHS Trust, Darlington Memorial Hospital, Darlington, United Kingdom.
⁷ Division of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁸ Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, Washington, USA.
⁹ Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, USA.
¹⁰ Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA.
¹¹ Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
¹² Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany.
¹³ Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹⁴ Divisions of Infectious Diseases and Respirology, University of Ottawa at the Ottawa Hospital, Ottawa, Canada.
¹⁵ Division of Molecular Biology and Human Genetics, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa.
¹⁶ Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA.

PMID: 37293702
PMCID: PMC10573724
DOI: 10.1093/cid/ciad356

Abstract

Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

Keywords: HIV exposure; Southern Africa; T-SPOT.TB; TB infection; infants.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. All authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

1. Jenkins HE, Yuen CM, Rodriguez CA, et al. . Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis 2017; 17:285–95. - PMC - PubMed
1. UNAIDS . UNAIDS data 2020 [Internet]. 2020. Available at: https://www.unaids.org/sites/default/files/media_asset/2020_aids-data-bo.... Accessed 21 February 2023.
1. Evans C, Jones CE, Prendergast AJ. HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination. Lancet Infect Dis 2016; 16:e92–e107. - PubMed
1. Flynn JL. Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinb) 2004; 84(1–2):93–101. - PubMed
1. Kidzeru EB, Hesseling AC, Passmore JA, et al. . In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants. AIDS 2014; 28:1421–30. - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

T32 AI007433/AI/NIAID NIH HHS/United States

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Affiliations

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Authors

Affiliations

Abstract

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical