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. 1986;52(2):173-82.
doi: 10.1007/BF00429321.

Regulation of nitrile-hydratase synthesis in a Brevibacterium species

D Tourneix, A Thiéry, M Maestracci, A Arnaud, P Galzy

Regulation of nitrile-hydratase synthesis in a Brevibacterium species

D Tourneix et al. Antonie Van Leeuwenhoek. 1986.

Abstract

The regulation of nitrile-hydratase biosynthese was studied in Brevibacterium sp R 312. Enzyme biosynthesis was not influenced by any carbon and nitrogen source used in the growth medium. It was, however, repressed by amide and amide analogues. Acetamide repressed nitrile-hydratase biosynthesis and induced the wide-spectrum amidase. Therefore, it appeared reasonable to hypothesize a single repressor gene for the nitrile-hydratase/wide-spectrum amidase system.

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