Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov;43(6):421-430.
doi: 10.1111/cpf.12840. Epub 2023 Jun 21.

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Alaa I Alyahya  1   2   3 , Sarah J Charman  1   2 , Nduka C Okwose  1   2   4 , Amy S Fuller  1   2 , Christopher Eggett  1   2 , Peter Luke  1   2 , Kristian Bailey  2 , Guy A MacGowan  2   5 , Djordje G Jakovljevic  1   2   4
Affiliations

Heart rate variability and haemodynamic function in individuals with hypertrophic cardiomyopathy

Alaa I Alyahya et al. Clin Physiol Funct Imaging. 2023 Nov.

Abstract

Objectives: Heart rate variability (HRV) is a measure of cardiac autonomic function. This study: (1) evaluated the differences in HRV and haemodynamic function between individuals with hypertrophic cardiomyopathy (HCM) and healthy controls, and (2) determined the relationship between HRV and haemodynamic variables in individuals with HCM.

Methods: Twenty-eight individuals with HCM (n = 7, females; age 54 ± 15 years; body mass index: 29 ± 5 kg/m2 ) and 28 matched healthy individuals (n = 7 females; age 54 ± 16 years; body mass index: 29 ± 5 kg/m2 ) completed 5-min HRV and haemodynamic measurements under resting (supine) conditions using bioimpedance technology. Frequency domain HRV measures (absolute and normalized low-frequency power (LF), high-frequency power (HF) and LF/HF ratio) and RR interval were recorded.

Results: Individuals with HCM demonstrated higher vagal activity (i.e., absolute unit of HF power (7.40 ± 2.50 vs. 6.03 ± 1.35 ms2 , p = 0.01) but lower RR interval (914 ± 178 vs. 1014 ± 168 ms, p = 0.03) compared to controls. Stroke volume (SV) index and cardiac index were lower in HCM compared with healthy individuals (SV, 33 ± 9 vs. 43 ± 7 ml‎/beat‎/m², p < 0.01; cardiac index,2.33 ± 0.42 vs. 3.57 ± 0.82 L/min/m2 , p < 0.01), but total peripheral resistance (TPR) was higher in HCM (3468 ± 1027 vs. 2953 ± 1050 dyn·s·m2 cm-5 , p = 0.03). HF power was significantly related to SV (r = -0.46, p < 0.01) and TPR (r = 0.28, p < 0.05) in HCM.

Conclusions: Short-term frequency domain indices of HRV provide a feasible approach to assess autonomic function in individuals with HCM. Vagal activity, represented by HF power, is increased, and associated with peripheral resistance in individuals with HCM.

Keywords: autonomic function; frequency domain; haemodynamic function; heart rate variability; hypertrophic cardiomyopathy.

PubMed Disclaimer

References

REFERENCES

    1. Abdulhameed, Y.A., McClintock, P.V.E. & Stefanovska, A. (2020) Race-specific differences in the phase coherence between blood flow and oxygenation: A simultaneous NIRS, white light spectroscopy and LDF study. Journal of Biophotonics, 13(4), 1-15.
    1. Ajiki, K., Murakawa, Y., Yanagisawa-Miwa, A., Usui, M., Yamashita, T., Oikawa, N. et al. (1993) Autonomic nervous system activity in idiopathic dilated cardiomyopathy and in hypertrophic cardiomyopathy. The American Journal of Cardiology, 71(15), 1316-1320.
    1. Ames, M.K., Atkins, C.E. & Pitt, B. (2019) The renin-angiotensin-aldosterone system and its suppression. Journal of Veterinary Internal Medicine, 33(2), 363-382.
    1. Arita, M., Miyai, N., Yamamoto, M., Kaneta, M., Utsumi, M., Uemastu, Y. et al. (2015) PP.12.01: influences of age on the results of blood pressure-reduction and autonomic nervous function in orthostatic changes. Journal of Hypertension, 33, e233.
    1. Bonaduce, D., Petretta, M., Betocchi, S., Ianniciello, A., Marciano, F., Apicella, C. et al. (1997) Heart rate variability in patients with hypertrophic cardiomyopathy: association with clinical and echocardiographic features. American Heart Journal, 134(2), 165-172.

LinkOut - more resources