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Review
. 2023 Sep-Oct;39(5):e3364.
doi: 10.1002/btpr.3364. Epub 2023 Jun 9.

Current status of platelet manufacturing in 3D or bioreactors

Soonho Kweon  1 , Suyeon Kim  1 , Hye Sook Choi  1 , Kyeongwon Jo  1 , Ju Mi Park  1 , Eun Jung Baek  1   2   3
Affiliations
Review

Current status of platelet manufacturing in 3D or bioreactors

Soonho Kweon et al. Biotechnol Prog. 2023 Sep-Oct.

Abstract

Blood shortages for transfusion are global issues of grave concern. As in vitro manufactured platelets are promising substitutes for blood donation, recent research has shown progresses including different cell sources, different bioreactors, and three-dimensional materials. The first-in-human clinical trial of cultured platelets using induced pluripotent stem cell-derived platelets began in Japan and demonstrated its quality, safety, and efficacy. A novel bioreactor with fluid motion for platelet production has been reported. Herein, we discuss various cell sources for blood cell production, recent advances in manufacturing processes, and clinical applications of cultured blood.

Keywords: bioreactors; cell culture technology; immortalized; platelets.

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References

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