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Comment
. 2023 Aug 4;13(8):1757.
doi: 10.1158/2159-8290.CD-RW2023-090.

A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth

No authors listed
Comment

A Pan-KRAS Inhibitor Impedes Common KRAS Oncoproteins and Tumor Growth

No authors listed. Cancer Discov. .

Abstract

A pan-KRAS inhibitor is selec-tive for the inactive state of multiple KRAS mutants, sparing other RAS isoforms.

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Comment on

  • Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
    Kim D, Herdeis L, Rudolph D, Zhao Y, Böttcher J, Vides A, Ayala-Santos CI, Pourfarjam Y, Cuevas-Navarro A, Xue JY, Mantoulidis A, Bröker J, Wunberg T, Schaaf O, Popow J, Wolkerstorfer B, Kropatsch KG, Qu R, de Stanchina E, Sang B, Li C, McConnell DB, Kraut N, Lito P. Kim D, et al. Nature. 2023 Jul;619(7968):160-166. doi: 10.1038/s41586-023-06123-3. Epub 2023 May 31. Nature. 2023. PMID: 37258666 Free PMC article.

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