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Comment
. 2023 Aug 4;13(8):1760.
doi: 10.1158/2159-8290.CD-RW2023-089.

The Tumor Suppressor CDKN2A Remodels the Lipidome of Glioblastoma

No authors listed
Comment

The Tumor Suppressor CDKN2A Remodels the Lipidome of Glioblastoma

No authors listed. Cancer Discov. .

Abstract

CDKN2A loss remodels the glioblastoma lipidome and sensitizes cells to lipid peroxidation and ferroptosis.

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  • CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis.
    Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. Minami JK, et al. Cancer Cell. 2023 Jun 12;41(6):1048-1060.e9. doi: 10.1016/j.ccell.2023.05.001. Epub 2023 May 25. Cancer Cell. 2023. PMID: 37236196 Free PMC article.

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