Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun:41 Suppl 1:48-56.
doi: 10.1002/hon.3139.

Post-transplant lymphoproliferative disease in children, adolescents, and young adults

Thomas G Gross  1 , Jeremy D Rubinstein  2   3
Affiliations
Review

Post-transplant lymphoproliferative disease in children, adolescents, and young adults

Thomas G Gross et al. Hematol Oncol. 2023 Jun.

Abstract

Post-transplant lymphoproliferative disease (PTLD) remains a major complication of transplantation. PTLD is a rare entity and very heterogenous making consensus on diagnosis and treatment very challenging. The majority are Epstein-Barr virus (EBV) driven, CD20+ B-cell proliferations. PTLD does occur following hematopoietic stem cell transplant (HSCT), but due to the relative short risk period and efficacy of pre-emptive therapy, PTLD following HSCT will not be discussed in this review. This review will focus on the epidemiology, role of EBV, clinical presentation, diagnosis and evaluation and the current and emerging treatment strategies for pediatric PTLD following solid organ transplantation.

Keywords: PTLD; post-transplant lymphoproliferative disease.

PubMed Disclaimer

References

REFERENCES

    1. Yanik EL, Smith JM, Shiels MS, et al. Cancer risk after pediatric solid organ transplantation. Pediatrics. 2017;139(5):e20163893. https://doi.org/10.1542/peds.2016-3893
    1. Yank EL, Smith JM, Shields MS, et al. Contribution of solid organ transplant recipients to the pediatric non-Hodgkin lymphoma burden in the United States. Cancer. 2017;123:4663-4671.
    1. Allen U, Hebert D, Moore D, Dror Y, Wasfy S, Canadian PSG. Epstein-Barr virus-related post-transplant lymphoproliferative disease in solid organ transplant recipients, 1988-97: a Canadian multi-centre experience. Pediatr Transplant. 2001;5(3):198-203. https://doi.org/10.1034/j.1399-3046.2001.00059.x
    1. Peters AC, Akinwumi MS, Cervera C, et al. The changing epidemiology of posttransplant lymphoproliferative disorder in adult solid organ transplant recipients over 30 years: a single-center experience. Transplantation. 2018;102(9):1553-1562. https://doi.org/10.1097/tp.0000000000002146
    1. Kinch A, Baecklund E, Backlin C, et al. A population-based study of 135 lymphomas after solid organ transplantation: the role of Epstein-Barr virus, hepatitis C and diffuse large B-cell lymphoma subtype in clinical presentation and survival. Acta Oncol. 2014;53(5):669-679. https://doi.org/10.3109/0284186x.2013.844853

MeSH terms