Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun:41 Suppl 1:129-135.
doi: 10.1002/hon.3145.

First line therapy of CLL

Michael Hallek  1   2   3
Affiliations

First line therapy of CLL

Michael Hallek. Hematol Oncol. 2023 Jun.

Abstract

Chronic lymphocytic leukemia (CLL) is one of the most frequent types of leukemia. It typically occurs in elderly patients and has a highly variable clinical course. Only patients with active or symptomatic disease or with advanced Binet or Rai stages require therapy. When treatment is indicated, several therapeutic options exist today and need to be selected. A combination of the BCL2 inhibitor venetoclax with obinutuzumab, monotherapy with inhibitors of Bruton tyrosine kinase (BTK) such as ibrutinib, acalabrutinib or zanubrutinib, while chemoimmunotherapy (CIT) is disappearing as a therapeutic option.

PubMed Disclaimer

References

REFERENCES

    1. The Surveillance E, and End Results (SEER) Program of the National Cancer Institute. Cancer Stat Facts: Leukemia - Chronic Lymphocytic Leukemia (CLL). [Internet]. 2021. Accessed 14 August 2021.
    1. Sant M, Allemani C, Tereanu C, et al. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010;116(19):3724-3734. https://doi.org/10.1182/blood-2010-05-282632
    1. Yang C, Zhang X. Incidence survey of leukemia in China. Chin Med Sci J. 1991;6(2):65-70.
    1. Bassig BA, Au WY, Mang O, et al. Subtype-specific incidence rates of lymphoid malignancies in Hong Kong compared to the United States, 2001-2010. Canc Epidemiol. 2016;42:15-23. https://doi.org/10.1016/j.canep.2016.02.007
    1. Hallek M, Cheson BD, Catovsky D, et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745-2760. https://doi.org/10.1182/blood-2017-09-806398

MeSH terms

Substances

LinkOut - more resources