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. 2023 Aug:228:72-80.
doi: 10.1016/j.thromres.2023.05.028. Epub 2023 Jun 5.

Contemporary trends in mortality related to high-risk pulmonary embolism in US from 1999 to 2019

Marco Zuin  1 , Behnood Bikdeli  2 , Julia Davies  3 , Darsiya Krishnathasan  3 , Gianluca Rigatelli  4 , Loris Roncon  5 , Claudio Bilato  6 , Gregory Piazza  3
Affiliations

Contemporary trends in mortality related to high-risk pulmonary embolism in US from 1999 to 2019

Marco Zuin et al. Thromb Res. 2023 Aug.

Abstract

Background: Population-based data on high-risk pulmonary embolism (PE) mortality trends in the United States (US) are scant.

Objectives: To assess current trends in US mortality related to high-risk PE over the past 21 years and determine differences by sex, race, ethnicity, age and census region.

Methods: Data were extracted from the Centers for Disease Control and Prevention (CDC) Wide-ranging ONline Data for Epidemiologic Research (WONDER) to determine trends in age-adjusted mortality rates (AAMR) per 100,000 people, due to high-risk PE. To calculate nationwide annual trends, we assessed the average (AAPC) and annual percent change (APC) with relative 95 % confidence intervals (CIs) using Joinpoint regression.

Results: Between 1999 and 2019, high-risk PE was listed as the underlying cause of death in 209,642 patients, corresponding to an AAMR of 3.01 per 100,000 people (95 % CI: 2.99 to 3.02). AAMR from high-risk PE remained stable from 1999 to 2007 [APC: -0.2 %, (95 % CI: -2.0 to 0.5, p = 0.22)] and then significantly increased [APC: 3.1 % (95 % CI: 2.6 to 3.6), p < 0.0001], especially in males [AAPC: 1.9 % (95 % CI: 1.4 to 2.4), p < 0.001 vs AAPC: 1.5 % (95 % CI: 1.1 to 2.2), p < 0.001]. AAMR increase was more pronounced in those <65 years, Black Americans, and residents of rural areas.

Conclusions: In an US population analysis, high-risk PE mortality rate increased, with racial, sex-based, and regional variations. Further studies are needed to understand root causes for these trends and to implement appropriate corrective strategies.

Keywords: Cardiogenic shock; Gender; Mortality; Pulmonary embolism; US mortality trends.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr Gregory Piazza reports a relationship with Bristol Myers that includes: funding grants. Dr Gregory Piazza reports a relationship with Pfizer alliance that includes: consulting or advisory and funding grants. Dr Gregory Piazza reports a relationship with Bayer that includes: funding grants. Dr Gregory Piazza reports a relationship with Janssen that includes: consulting or advisory and funding grants. Dr Gregory Piazza reports a relationship with Alexion that includes: funding grants. Dr Gregory Piazza reports a relationship with Amgen that includes: consulting or advisory and funding grants. Dr Gregory Piazza reports a relationship with Boston Scientific Corp that includes: consulting or advisory and funding grants. Dr Behnood Bikdeli reports a relationship with Scott Schoen Award that includes: funding grants. Dr Behnood Bikdeli reports a relationship with Nancy Adams IGNITE Award that includes:. Dr Behnood Bikdeli reports a relationship with Mary Ann Tynan Research that includes: funding grants. Dr. Bikdeli is a recipient of a Career Development Award from the American Heart Association and VIVA Physicians (#938814).

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