Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Aug:61:152230.
doi: 10.1016/j.semarthrit.2023.152230. Epub 2023 Jun 2.

Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review

Eugenia Y Chock  1 , Sovit Dahal  2 , Alyssa A Grimshaw  3 , Lisa Suter  4 , Zeyan Liew  5 , David Felson  6
Affiliations

Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review

Eugenia Y Chock et al. Semin Arthritis Rheum. 2023 Aug.

Abstract

Introduction: Most women with rheumatic diseases discontinue antirheumatic therapies in anticipation of, or during pregnancy due to concerns around medication safety and fetal wellbeing.

Objective: We performed a scoping review of available evidence investigating the risks of adverse offspring neurodevelopmental outcomes amongst parents with chronic inflammatory arthritis, taking antirheumatic therapies during conception or pregnancy.

Methods: We designed a scoping review protocol and search strategy a priori in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We performed an exhaustive search in Cochrane Library, Embase, Google Scholar, Medline, and Web of Science for relevant literature in January 2023. Articles needed to include offspring neurodevelopmental outcomes born to parents with CIA who took antirheumatic therapies during conception or pregnancy. Independent reviewers extracted data from eligible articles using a standard abstraction tool and performed critical appraisal of study quality.

Results: Six studies were included for full data abstraction. Use of Nonsteroidal Anti-inflammatory Drugs, Tumor Necrosis Factor Alpha inhibitors, and exposure to methotrexate during early first trimester of pregnancy did not seem to increase risk for adverse offspring neurodevelopmental outcomes. Corticosteroid use during pregnancy seemed to pose an increased risk for attention deficit hyperactive disorders in offspring.

Conclusion: Use of some antirheumatic therapies during pregnancy may not be associated with adverse offspring neurodevelopmental outcomes. Further investigations are needed to elucidate if other confounding factors affect long term offspring health outcomes born to parents with chronic inflammatory arthritis.

Keywords: Antirheumatic Medications; Chronic Inflammatory Arthritis; Offspring Outcomes; Pregnancy.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
PRISMA Flowchart of Included Studies.
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. Data and statistics about ADHD. https://www.cdc.gov/ncbddd/adhd/data.html Web site. Accessed January 23, 2023.
    1. Kogan MD, Vladutiu CJ, Schieve LA, et al. The prevalence of parent-reported autism spectrum disorder among US children. Pediatrics. 2018;142(6):e20174161. doi: 10.1542/peds.2017-4161. doi: 10.1542/peds.2017-4161. - DOI - DOI - PMC - PubMed
    1. He H, Yu Y, Liew Z, et al. Association of maternal autoimmune diseases with risk of mental disorders in offspring in denmark. JAMA Netw Open. 2022;5(4):e227503. 10.1001/jamanetworkopen.2022.7503. doi: 10.1001/jamanetworkopen.2022.7503. - DOI - DOI - PMC - PubMed
    1. Bomba M, Galli J, Nacinovich R, et al. Neuropsychiatric aid in children born to patients with rheumatic diseases. Clin Exp Rheumatol. 2010;28(5):767–773. doi: 893 [pii]. - PubMed
    1. Lahita RG. Systemic lupus erythematosus: Learning disability in the male offspring of female patients and relationship to laterality. Psychoneuroendocrinology. 1988;13(5):385–396. doi: 10.1016/0306-4530(88)90045-5. - DOI - PubMed

Publication types

Substances