Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma

Abstract

Benign lymphadenopathy is common in the pediatric population and may be clinically striking. As in adults, lymph node evaluation in pediatric patients requires careful morphologic and immunohistochemical assessment and clinical contextualization of the findings. It is important for the pathologist to be familiar with benign and reactive conditions that may mimic malignancy. This review presents non-neoplastic or indolent processes or patterns of lymphoid hyperplasia that may be confused with or raise the differential of lymphoma, with a focus on those more commonly encountered in the pediatric/adolescent population.

Keywords: Follicular hyperplasia; Hematogones; Kikuchi; Lymphadenopathy; PTGC; Pediatric; Progressive transformation of germinal centers; iTLP.