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Review
. 2023 Nov;40(6):371-378.
doi: 10.1053/j.semdp.2023.05.004. Epub 2023 Jun 1.

Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma

Rachel A Mariani  1 , Elizabeth L Courville  2
Affiliations
Review

Reactive Lymphadenopathy in the Pediatric Population with a Focus on Potential Mimics of Lymphoma

Rachel A Mariani et al. Semin Diagn Pathol. 2023 Nov.

Abstract

Benign lymphadenopathy is common in the pediatric population and may be clinically striking. As in adults, lymph node evaluation in pediatric patients requires careful morphologic and immunohistochemical assessment and clinical contextualization of the findings. It is important for the pathologist to be familiar with benign and reactive conditions that may mimic malignancy. This review presents non-neoplastic or indolent processes or patterns of lymphoid hyperplasia that may be confused with or raise the differential of lymphoma, with a focus on those more commonly encountered in the pediatric/adolescent population.

Keywords: Follicular hyperplasia; Hematogones; Kikuchi; Lymphadenopathy; PTGC; Pediatric; Progressive transformation of germinal centers; iTLP.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.