Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May 25;13(11):1842.
doi: 10.3390/diagnostics13111842.

Linear EUS Accuracy in Preoperative Staging of Gastric Cancer: A Retrospective Multicenter Study

Germana de Nucci  1 , Tommaso Gabbani  2 , Giovanna Impellizzeri  2 , Simona Deiana  2 , Paolo Biancheri  2 , Laura Ottaviani  2 , Leonardo Frazzoni  3 , Enzo Domenico Mandelli  1 , Paola Soriani  2 , Maurizio Vecchi  4 , Gianpiero Manes  1 , Mauro Manno  2
Affiliations

Linear EUS Accuracy in Preoperative Staging of Gastric Cancer: A Retrospective Multicenter Study

Germana de Nucci et al. Diagnostics (Basel). .

Abstract

Introduction: Preoperative gastric cancer (GC) staging is the most reliable prognostic factor that affects therapeutic strategies. Contrast-enhanced computed tomography (CECT) and radial endoscopic ultrasound (R-EUS) scans are the most commonly used staging tools for GC. The accuracy of linear EUS (L-EUS) in this setting is still controversial. The aim of this retrospective multicenter study was to evaluate the accuracy of L-EUS and CECT in preoperative GC staging, with regards to depth of tumor invasion (T staging) and nodal involvement (N staging).

Materials and methods: 191 consecutive patients who underwent surgical resection for GC were retrospectively enrolled. Preoperative staging had been performed using both L-EUS and CECT, and the results were compared to postoperative staging by histopathologic analysis of surgical specimens.

Results: L-EUS diagnostic accuracy for depth of invasion of the GC was 100%, 60%, 74%, and 80% for T1, T2, T3, and T4, respectively. CECT accuracy for T staging was 78%, 55%, 45%, and 10% for T1, T2, T3, and T4, respectively. L-EUS diagnostic accuracy for N staging of GC was 85%, significantly higher than CECT accuracy (61%).

Conclusions: Our data suggest that L-EUS has a higher accuracy than CECT in preoperative T and N staging of GC.

Keywords: diagnostic accuracy; gastric cancer staging; linear endoscopic ultrasound.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Comparison of linear EUS and CECT ROC curves in preoperative N staging of gastric cancer.
See this image and copyright information in PMC

References

    1. Tsendsuren T., Jun S.M., Mian X.H. Usefulness of endoscopic ultrasonography in preoperative TNM staging in gastric cancer. World J. Gastroenterol. 2006;12:43–47. doi: 10.3748/wjg.v12.i1.43. - DOI - PMC - PubMed
    1. Shimoyama S., Yasuda H., Hashimoto M., Tatsutomi Y., Aoki F., Mafune K.-I., Kaminishi M. Accuracy of linear-array EUS for preoperative staging of gastric cardia cancer. Gastrointest. Endosc. 2004;60:50–55. doi: 10.1016/S0016-5107(04)01312-4. - DOI - PubMed
    1. Bunting D., Bracey T., Fox B., Berrisford R., Wheatley T., Sanders G. Loco-regional staging accuracy in oesophageal cancer-How good are we in the modern era? Eur. J. Radiol. 2017;97:71–75. doi: 10.1016/j.ejrad.2017.10.015. - DOI - PubMed
    1. Ungureanu B.S., Sacerdotianu V.M., Turcu-Stiolica A., Cazacu I.M., Saftoiu A. Endoscopic Ultrasound vs. Computed Tomography for Gastric Cancer Staging: A Network Meta-Analysis. Diagnostics. 2021;11:134. doi: 10.3390/diagnostics11010134. - DOI - PMC - PubMed
    1. Mehmedović A., Mesihović R., Saray A., Vanis N. Gastric cancer staging: EUS and CT. Med. Arch. 2014;68:34–36. doi: 10.5455/medarh.2014.68.34-36. - DOI - PMC - PubMed

LinkOut - more resources