Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 May 23;15(11):2872.
doi: 10.3390/cancers15112872.

Calcium Homeostasis in the Development of Resistant Breast Tumors

Desirée Martin-García  1   2 , Teresa Téllez  1   2   3 , Maximino Redondo  1   2   3   4 , Marilina García-Aranda  2   3   4
Affiliations
Review

Calcium Homeostasis in the Development of Resistant Breast Tumors

Desirée Martin-García et al. Cancers (Basel). .

Abstract

Cancer is one of the main health problems worldwide. Only in 2020, this disease caused more than 19 million new cases and almost 10 million deaths, with breast cancer being the most diagnosed worldwide. Today, despite recent advances in breast cancer treatment, a significant percentage of patients will either not respond to therapy or will eventually experience lethal progressive disease. Recent studies highlighted the involvement of calcium in the proliferation or evasion of apoptosis in breast carcinoma cells. In this review, we provide an overview of intracellular calcium signaling and breast cancer biology. We also discuss the existing knowledge on how altered calcium homeostasis is implicated in breast cancer development, highlighting the potential utility of Ca2+ as a predictive and prognostic biomarker, as well as its potential for the development of new pharmacological treatments to treat the disease.

Keywords: Ca2+ channels; breast cancer; calcium; homeostasis; resistant tumors; targeted therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Progression of breast cancer in the different stages according to the traditional TNM staging system. Images were created using Biorender.com.
Figure 2
Figure 2
Ca2+ channels and pumps involved in cell homeostasis. Images were created using Biorender.com.
Figure 3
Figure 3
Conventional electrochemotherapy ((A) intravenous injection, (B) application of electrical pulses and (C) tumor cell death) versus Ca2+ electroporation ((1) application of electrical pulses, (2) supraphysiological calcium doses, (3) calcium transport and (4) tumor cell death). Images were created using Biorender.com.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Sung H., Ferlay J., Siegel R.L., Laversanne M., Soerjomataram I., Jemal A., Bray F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021;71:209–249. doi: 10.3322/caac.21660. - DOI - PubMed
    1. Shulman L.N., Willett W., Sievers A., Knaul F.M. Breast cancer in developing countries: Opportunities for improved survival. J. Oncol. 2010;2010:595167. doi: 10.1155/2010/595167. - DOI - PMC - PubMed
    1. Shemanko C.S., Cong Y., Forsyth A. What is the breast in the bone? Int. J. Mol. Sci. 2016;17:1764. doi: 10.3390/ijms17101764. - DOI - PMC - PubMed
    1. Bloom A.P., Jiménez-Andrade J.M., Taylor R.N., Castañeda-Corral G., Kaczmarska M.J., Freeman K.T., Coughlin K.A., Guilardi J.R., Kuskowsik M.A., Mantyh P.W. Breast cancer-induced bone remodeling, skeletal pain and tenderness flare nerve fibers. J. Pain. 2011;12:698–711. doi: 10.1016/j.jpain.2010.12.016. - DOI - PMC - PubMed
    1. Takeshima H., Ushijima T. Accumulation of genetic and epigenetic alterations in normal cells and cancer risk. NPJ Precis. Oncol. 2019;3:7. doi: 10.1038/s41698-019-0079-0. - DOI - PMC - PubMed

LinkOut - more resources