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Review
. 2023 May 26;15(11):2932.
doi: 10.3390/cancers15112932.

Overview of Molecular Detection Technologies for MET in Lung Cancer

Carina Heydt  1 , Michaela Angelika Ihle  1 , Sabine Merkelbach-Bruse  1
Affiliations
Review

Overview of Molecular Detection Technologies for MET in Lung Cancer

Carina Heydt et al. Cancers (Basel). .

Abstract

MET tyrosine kinase receptor pathway activation has become an important actionable target in solid tumors. Aberrations in the MET proto-oncogene, including MET overexpression, the activation of MET mutations, MET mutations that lead to MET exon 14 skipping, MET gene amplifications, and MET fusions, are known to be primary and secondary oncogenic drivers in cancer; these aberrations have evolved as predictive biomarkers in clinical diagnostics. Thus, the detection of all known MET aberrations in daily clinical care is essential. In this review, current molecular technologies for the detection of the different MET aberrations are highlighted, including the benefits and drawbacks. In the future, another focus will be on the standardization of detection technologies for the delivery of reliable, quick, and affordable tests in clinical molecular diagnostics.

Keywords: MET; MET exon 14 skipping mutation; MET fusion; MET gene amplification; NSCLC.

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Conflict of interest statement

Carina Heydt has received honoraria from AstraZeneca, BMS, Illumina, and Molecular Health; Michaela Angelika Ihle has received honoraria from AstraZeneca, BMS, Novartis, and Merck; Sabine Merkelbach-Bruse has received honoraria and travel support from Amgen, AstraZeneca, Bayer, BMS, GSK, Janssen, Merck, MSD, Molecular Health, Novartis, Pfizer, QuIP, Roche, and Targos.

Figures

Figure 1
Figure 1
Schematic representation of MET aberrations in the MET receptor.
Figure 2
Figure 2
Clinical utility of the analysis of tumor material in molecular pathology diagnostics over time.
See this image and copyright information in PMC

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