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Review
. 2023 May 29;15(11):2967.
doi: 10.3390/cancers15112967.

The Role of MRI and PET/CT in Radiotherapy Target Volume Determination in Gastrointestinal Cancers-Review of the Literature

Ajra Secerov Ermenc  1   2 , Barbara Segedin  1   2
Affiliations
Review

The Role of MRI and PET/CT in Radiotherapy Target Volume Determination in Gastrointestinal Cancers-Review of the Literature

Ajra Secerov Ermenc et al. Cancers (Basel). .

Abstract

Positron emission tomography with computed tomography (PET/CT) and magnetic resonance imaging (MRI) could improve accuracy in target volume determination for gastrointestinal cancers. A systematic search of the PubMed database was performed, focusing on studies published within the last 20 years. Articles were considered eligible for the review if they included patients with anal canal, esophageal, rectal or pancreatic cancer, as well as PET/CT or MRI for radiotherapy treatment planning, and if they reported interobserver variability or changes in treatment planning volume due to different imaging modalities or correlation between the imaging modality and histopathologic specimen. The search of the literature retrieved 1396 articles. We retrieved six articles from an additional search of the reference lists of related articles. Forty-one studies were included in the final review. PET/CT seems indispensable for target volume determination of pathological lymph nodes in esophageal and anal canal cancer. MRI seems appropriate for the delineation of primary tumors in the pelvis as rectal and anal canal cancer. Delineation of the target volumes for radiotherapy of pancreatic cancer remains challenging, and additional studies are needed.

Keywords: MRI; PET/CT; anal canal cancer; esophageal cancer; interobserver variability; pancreatic cancer; rectal cancer; target volume determination.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Search flow-chart according to the PRISMA guidelines.
Figure 2
Figure 2
Anal cancer on different imaging modalities. (A) Computed tomography (CT). (B) 18-F-fluorodeoxyglucose positron emission tomography CT. (C) Magnetic resonance imaging (MRI). (D) a combination of CT and MRI. White arrow: primary tumor of anal canal.
Figure 3
Figure 3
Esophageal cancer on different imaging modalities. (A) Computed tomography (CT). (B) 18-F-fluorodeoxyglucose positron emission tomography CT (FDG-PET/CT). (C) Magnetic resonance imaging (MRI). (D) combination of CT and MRI. White arrow: primary tumor of the esophagus.
See this image and copyright information in PMC

References

    1. World Health Organization International Agency for Research on Cancer (IARC) GLOBOCAN 2020: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2020. [(accessed on 20 January 2023)]. Available online: http://globocan.iarc.fr/
    1. Beaton L., Bandula S., Gaze M.N., Sharma R.A. How rapid advances in imaging are defining the future of precision radiation oncology. Br. J. Cancer. 2019;120:779–790. doi: 10.1038/s41416-019-0412-y. - DOI - PMC - PubMed
    1. Decazes P., Hinault P., Veresezan O., Thureau S., Gouel P., Vera P. Trimodality PET/CT/MRI and Radiotherapy: A Mini-Review. Front. Oncol. 2021;10:614008. doi: 10.3389/fonc.2020.614008. - DOI - PMC - PubMed
    1. Lambrecht M., Haustermans K. Clinical evidence on PET-CT for radiation therapy planning in gastro-intestinal tumors. Radiother. Oncol. 2010;96:339–346. doi: 10.1016/j.radonc.2010.07.019. - DOI - PubMed
    1. Mahmud A., Poon R., Jonker D. PET imaging in anal canal cancer: A systematic review and meta-analysis. Br. J. Radiol. 2017;90:1080. doi: 10.1259/bjr.20170370. - DOI - PMC - PubMed

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