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Review
. 2023 May 26;20(11):5962.
doi: 10.3390/ijerph20115962.

Prevention of Type 1 Diabetes in Children: A Worthy Challenge?

Diletta Maria Francesca Ingrosso  1 , Maria Teresa Quarta  1 , Alessia Quarta  1 , Francesco Chiarelli  1
Affiliations
Review

Prevention of Type 1 Diabetes in Children: A Worthy Challenge?

Diletta Maria Francesca Ingrosso et al. Int J Environ Res Public Health. .

Abstract

Nowadays, the development of new immuno-therapeutic drugs has made it possible to alter the course of many autoimmune diseases. Type 1 diabetes is a chronic disease with a progressive dependence on exogenous insulin administration. The ability to intercept individuals at high risk of developing type 1 diabetes is the first step toward the development of therapies that can delay the process of β-cell destruction, thus permitting a better glycemic control and reducing the incidence of ketoacidosis. The knowledge of the main pathogenetic mechanisms underlying the three stages of the disease may be helpful to identify the best immune therapeutic approach. In this review, we aim to give an overview of the most important clinical trials conducted during the primary, secondary and tertiary phases of prevention.

Keywords: autoimmunity; prevention; screening; type 1 diabetes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Types of prevention according to T1D stages.
Figure 2
Figure 2
Main prevention and treatment options for different stages of T1D.
See this image and copyright information in PMC

References

    1. Primavera M., Giannini C., Chiarelli F. Prediction and Prevention of Type 1 Diabetes. Front. Endocrinol. Lausanne. 2020;11:248. doi: 10.3389/fendo.2020.00248. - DOI - PMC - PubMed
    1. Ogle G.D., James S., Dabelea D., Pihoker C., Svennson J., Maniam J., Klatman E.L., Patterson C.C. Global estimates of incidence of type 1 diabetes in children and adolescents: Results from the International Diabetes Federation Atlas, 10th edition. Diabetes Res. Clin. Pract. 2022;183:109083. doi: 10.1016/j.diabres.2021.109083. - DOI - PubMed
    1. DiMeglio L.A., Evans-Molina C., Oram R.A. Type 1 diabetes. Lancet. 2018;391:2449–2462. doi: 10.1016/S0140-6736(18)31320-5. - DOI - PMC - PubMed
    1. Kelly M.A. Molecular aspects of type 1 diabetes. Mol. Pathol. 2003;56:1–10. doi: 10.1136/mp.56.1.1. - DOI - PMC - PubMed
    1. Redondo M.J., Steck A.K., Pugliese A. Genetics of type 1 diabetes. Pediatr. Diabetes. 2018;19:346–353. doi: 10.1111/pedi.12597. - DOI - PMC - PubMed