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. 2023 Jun 5;11(11):1658.
doi: 10.3390/healthcare11111658.

Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study

Tu Cam Nguyen  1   2 , Ngoc Le Chau Tang  3 , Giao Kim Ngoc Le  4 , Vy Thuy Nguyen  5 , Khuong Hoang Gia Nguyen  6 , Thai Hoang Che  6 , Van Thi Tuong Phan  1 , Ngoc Minh Nguyen  3 , Dinh Quang Truong  7 , Xuan Minh Ngo  8 , Hiep Thanh Nguyen  9 , Annie Robert  10 , Patrick Bontems  2   11 , Phuong Ngoc Van Nguyen  6
Affiliations

Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study

Tu Cam Nguyen et al. Healthcare (Basel). .

Abstract

Background: Helicobacter pylori (H. pylori) remains a major cause of gastroduodenal diseases. We aimed to evaluate the burden of this infection, particularly peptic ulcer disease in Vietnamese children.

Methods: We enrolled consecutive children referred for esophagogastroduodenoscopy at two tertiary children's hospitals in Ho Chi Minh City, from October 2019 to May 2021. Children treated with proton pump inhibitors during the last two weeks or antibiotics for four weeks, and those having a previous or interventional endoscopy were excluded. H. pylori infection was diagnosed with either a positive culture or positive histopathology combined with a rapid urease test, or with a polymerase chain reaction of the urease gene. The study was approved by the Ethics Committee and written informed consent/assent was obtained.

Results: Among 336 enrolled children aged 4-16 (mean: 9.1 ± 2.4 years; 55.4% girls), H. pylori infection was positive in 80%. Peptic ulcers were detected in 65 (19%), increasing with age, and 25% with anemia. cagA+ strains were detected at a higher rate in children with ulcers.

Conclusions: Prevalence of H. pylori and peptic ulcers is high among symptomatic Vietnamese children. It is crucial to have a program for early detection of H. pylori to reduce ulcer risk and gastric cancer later.

Keywords: Helicobacter pylori; biopsy-based tests; peptic ulcer disease; symptomatic children; virulence factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study series.
Figure 2
Figure 2
Distribution of H. pylori infection according to age group and gender.
See this image and copyright information in PMC

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