doi: 10.1111/j.2042-7158.1979.tb13504.x.
The protection of primates against soman poisoning by pretreatment with pyridostigmine
- PMID: 37298
- DOI: 10.1111/j.2042-7158.1979.tb13504.x
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The protection of primates against soman poisoning by pretreatment with pyridostigmine
J Pharm Pharmacol.
1979 May.
Abstract
The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. The protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species.
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