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. 2023 Jun 2;12(11):3821.
doi: 10.3390/jcm12113821.

Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19

Alba Mulet  1 , Iván J Núñez-Gil  2 , Juan Antonio Carbonell  3 , Joan B Soriano  4   5 , María C Viana-Llamas  6 , Sergio Raposeiras-Roubin  7 , Rodolfo Romero  8 , Emilio Alfonso-Rodríguez  9 , Aitor Uribarri  10 , Gisela Feltes  11 , Victor M Becerra-Muñoz  12 , Francesco Santoro  13 , Martino Pepe  14 , Alex F Castro-Mejía  15 , David Chipayo  16 , Miguel Corbi-Pascual  17 , Javier López-Pais  18 , Oscar Vedia  19 , Edoardo Manzone  20 , Germán Molina-Romera  21 , Carolina Espejo-Paeres  22 , Álvaro López-Masjuan  23 , Lazar Velicki  24   25 , Antonio Fernández-Ortiz  2 , Ibrahim El-Battrawy  26 , Jaime Signes-Costa  1 , On Behalf Of Hope Team
Affiliations

Clinical Profile and Determinants of Mortality in Patients with Interstitial Lung Disease Admitted for COVID-19

Alba Mulet et al. J Clin Med. .

Abstract

Background: Concern has risen about the effects of COVID-19 in interstitial lung disease (ILD) patients. The aim of our study was to determine clinical characteristics and prognostic factors of ILD patients admitted for COVID-19.

Methods: Ancillary analysis of an international, multicenter COVID-19 registry (HOPE: Health Outcome Predictive Evaluation) was performed. The subgroup of ILD patients was selected and compared with the rest of the cohort.

Results: A total of 114 patients with ILDs were evaluated. Mean ± SD age was 72.4 ± 13.6 years, and 65.8% were men. ILD patients were older, had more comorbidities, received more home oxygen therapy and more frequently had respiratory failure upon admission than non-ILD patients (all p < 0.05). In laboratory findings, ILD patients more frequently had elevated LDH, C-reactive protein, and D-dimer levels (all p < 0.05). A multivariate analysis showed that chronic kidney disease and respiratory insufficiency on admission were predictors of ventilatory support, and that older age, kidney disease and elevated LDH were predictors of death.

Conclusions: Our data show that ILD patients admitted for COVID-19 are older, have more comorbidities, more frequently require ventilatory support and have higher mortality than those without ILDs. Older age, kidney disease and LDH were independent predictors of mortality in this population.

Keywords: COVID-19; interstitial lung diseases; mortality; ventilatory support.

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Conflict of interest statement

The authors declare no conflict of interest.

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