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. 2023 May 28;24(11):9416.
doi: 10.3390/ijms24119416.

Vitamin D and Bone fragility in Individuals with Osteogenesis Imperfecta: A Scoping Review

Maria Gnoli  1 , Evelise Brizola  1 , Morena Tremosini  1 , Alessia Di Cecco  1 , Luca Sangiorgi  1
Affiliations

Vitamin D and Bone fragility in Individuals with Osteogenesis Imperfecta: A Scoping Review

Maria Gnoli et al. Int J Mol Sci. .

Abstract

Vitamin D affects several body functions, and thus general health, due to its pleiotropic activity. It plays a key role in bone metabolism, and its deficiency impacts bone development, leading to bone fragility. In osteogenesis imperfecta (OI), a group of hereditary connective tissue disorders characterized by bone fragility, additional factors, such as vitamin D deficiency, can affect the expression of the phenotype and aggravate the disorder. The aim of this scoping review was to assess the incidence of vitamin D deficit in OI patients and the association between vitamin D status and supplementation in individuals affected by OI. We searched the PubMed Central and Embase databases and included studies published between January/2000 and October/2022 evaluating vitamin D measurement and status (normal, insufficiency, deficiency) and supplementation for OI. A total of 263 articles were identified, of which 45 were screened by title and abstract, and 10 were included after a full-text review. The review showed that low levels of vitamin D was a frequent finding in OI patients. Vitamin D supplementation was mainly indicated along with drug therapy and calcium intake. Even if widely used in clinical practice, vitamin D supplementation for OI individuals still needs a better characterization and harmonized frame for its use in the clinical setting, as well as further studies focusing on its effect on bone fragility.

Keywords: adults; children; measurement; osteogenesis imperfecta; supplementation; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

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Figure 1
PRISMA flowchart.
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