Occurrence of Alkenylbenzenes in Plants: Flavours and Possibly Toxic Plant Metabolites
- PMID: 37299054
- PMCID: PMC10255789
- DOI: 10.3390/plants12112075
Occurrence of Alkenylbenzenes in Plants: Flavours and Possibly Toxic Plant Metabolites
Abstract
Alkenylbenzenes are naturally occurring secondary plant metabolites. While some of them are proven genotoxic carcinogens, other derivatives need further evaluation to clarify their toxicological properties. Furthermore, data on the occurrence of various alkenylbenzenes in plants, and especially in food products, are still limited. In this review, we tempt to give an overview of the occurrence of potentially toxic alkenylbenzenes in essential oils and extracts from plants used for flavoring purposes of foods. A focus is layed on widely known genotoxic alkenylbenzenes, such as safrole, methyleugenol, and estragole. However, essential oils and extracts that contain other alkenylbenzenes and are also often used for flavoring purposes are considered. This review may re-raise awareness of the need for quantitative occurrence data for alkenylbenzenes in certain plants but especially in final plant food supplements, processed foods, and flavored beverages as the basis for a more reliable exposure assessment of alkenylbenzenes in the future.
Keywords: alkenylbenzenes; apiol; culinary spices; essential oils; estragole; herbs; methyleugenol; myristicin; safrole.
Conflict of interest statement
The authors declare no conflict of interest.
Similar articles
-
Comparative Analysis of Estragole, Methyleugenol, Myristicin, and Elemicin Regarding Micronucleus Formation in V79 Cells.Molecules. 2025 Feb 10;30(4):806. doi: 10.3390/molecules30040806. Molecules. 2025. PMID: 40005118 Free PMC article.
-
Alkenylbenzenes in Foods: Aspects Impeding the Evaluation of Adverse Health Effects.Foods. 2021 Sep 10;10(9):2139. doi: 10.3390/foods10092139. Foods. 2021. PMID: 34574258 Free PMC article. Review.
-
Myristicin and Elemicin: Potentially Toxic Alkenylbenzenes in Food.Foods. 2022 Jul 5;11(13):1988. doi: 10.3390/foods11131988. Foods. 2022. PMID: 35804802 Free PMC article. Review.
-
A computational study on the biotransformation of alkenylbenzenes by a selection of CYPs: Reflections on their possible bioactivation.Toxicology. 2023 Apr;488:153471. doi: 10.1016/j.tox.2023.153471. Epub 2023 Feb 28. Toxicology. 2023. PMID: 36863505
-
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.Cancer Res. 1983 Mar;43(3):1124-34. Cancer Res. 1983. PMID: 6825084
Cited by
-
Environmental and internal drivers of genotoxic carcinogens accumulation in botanicals and their preparations.Arch Toxicol. 2025 Jul 11. doi: 10.1007/s00204-025-04123-y. Online ahead of print. Arch Toxicol. 2025. PMID: 40646165 Review.
-
In Silico Network Toxicology, Molecular Docking, and Multi-Level Bioinformatics Reveal Methyl Eugenol-Induced Hepatocellular Carcinoma Mechanisms in Humans.Cancer Med. 2025 May;14(10):e70768. doi: 10.1002/cam4.70768. Cancer Med. 2025. PMID: 40370109 Free PMC article.
-
Study of the Effect of Methyl Eugenol on Gastric Damage Produced by Spinal Cord Injury Model in the Rat.Molecules. 2024 Dec 29;30(1):86. doi: 10.3390/molecules30010086. Molecules. 2024. PMID: 39795143 Free PMC article.
-
Comparative Analysis of Estragole, Methyleugenol, Myristicin, and Elemicin Regarding Micronucleus Formation in V79 Cells.Molecules. 2025 Feb 10;30(4):806. doi: 10.3390/molecules30040806. Molecules. 2025. PMID: 40005118 Free PMC article.
References
-
- Burdock G.A. Fenaroli’s Handbook of Flavor Ingredients. 6th ed. CRC Press; Boca Raton, FL, USA: 2009.
Publication types
LinkOut - more resources
Full Text Sources