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. 2023 May 26;15(11):2477.
doi: 10.3390/nu15112477.

The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review

Laila Salameh  1   2 , Walid Mahmood  1 , Rifat Hamoudi  2   3 , Khulood Almazrouei  4 , Mahesh Lochanan  2 , Suheyl Seyhoglu  2 , Bassam Mahboub  2
Affiliations

The Role of Vitamin D Supplementation on Airway Remodeling in Asthma: A Systematic Review

Laila Salameh et al. Nutrients. .

Abstract

Asthma is a common chronic respiratory disease that affects millions of people worldwide, and its prevalence continues to increase. Vitamin D has been proposed as a potential environmental factor in asthma pathogenesis, due to its immunomodulatory effects. This systematic review aimed to evaluate the effect of vitamin D supplementation in order to prevent airway remodeling in asthmatic patients. Four electronic databases, namely PubMed, Embase, Clinical trails.gov, and CINAHL, were thoroughly searched to conduct a comprehensive literature review. The International Prospective Register of Systematic Reviews (CRD42023413798) contains a record of the registered protocol. We identified 9447 studies during the initial search; 9 studies (0.1%) met the inclusion criteria and were included in the systematic review. All included studies were experimental studies that investigated the impact of vitamin D supplementation on airway remodeling in asthma. The studies included in this review suggest that vitamin D inhibits airway smooth muscle cell contraction and remodeling, reduces inflammation, regulates collagen synthesis in the airways, and modulates the action of bronchial fibroblasts. However, one study suggests that TGF-β1 can impair vitamin D-induced and constitutive airway epithelial host defense mechanisms. Overall, vitamin D appears to have a potential role in the prevention and management of asthma.

Keywords: airway remodeling; asthma; inflammation; smooth muscle cell; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart depicting the study selection process according to inclusion and exclusion criteria.
See this image and copyright information in PMC

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