Is Hypertrophic Cardiomyopathy Always a Familial and Inherited Disease?

doi:10.1161/JAHA.122.028974

. 2023 Jun 20;12(12):e028974.

doi: 10.1161/JAHA.122.028974. Epub 2023 Jun 10.

Is Hypertrophic Cardiomyopathy Always a Familial and Inherited Disease?

Jiri Bonaventura^{1

2}, Ethan J Rowin¹, Martin S Maron¹, Barry J Maron¹

Affiliations

¹ Hypertrophic Cardiomyopathy Center Lahey Hospital and Medical Center Burlington MA USA.
² Department of Cardiology, 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czech Republic.

PMID: 37301765
PMCID: PMC10356023
DOI: 10.1161/JAHA.122.028974

Is Hypertrophic Cardiomyopathy Always a Familial and Inherited Disease?

Jiri Bonaventura et al. J Am Heart Assoc. 2023.

. 2023 Jun 20;12(12):e028974.

doi: 10.1161/JAHA.122.028974. Epub 2023 Jun 10.

Authors

Jiri Bonaventura^{1

2}, Ethan J Rowin¹, Martin S Maron¹, Barry J Maron¹

Affiliations

¹ Hypertrophic Cardiomyopathy Center Lahey Hospital and Medical Center Burlington MA USA.
² Department of Cardiology, 2nd Faculty of Medicine Charles University and Motol University Hospital Prague Czech Republic.

PMID: 37301765
PMCID: PMC10356023
DOI: 10.1161/JAHA.122.028974

No abstract available

Keywords: familial; genetics; hypertrophic cardiomyopathy; inheritance.

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Figures

**Figure 1. Four study pedigrees demonstrating the nonfamilial form of hypertrophic cardiomyopathy (HCM).**
Clear symbols indicate absence of evidence of HCM; solid symbols, clinically confirmed HCM; and symbols with slash, died of non‐HCM disease. Subject ages are in parentheses. Arrows indicate probands.

See this image and copyright information in PMC

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References

1. Maron BJ. Clinical course and management of hypertrophic cardiomyopathy. N Engl J Med. 2018;379:655–666. doi: 10.1056/NEJMra1710575 - DOI - PubMed
1. Chou C, Chin MT. Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction. Int J Mol Sci. 2021;22:8933. doi: 10.3390/ijms22168933 - DOI - PMC - PubMed
1. Braunwald E, Lambrew CT, Rockoff SD, Ross J Jr, Morrow AG. Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation. 1964;30:3–119. doi: 10.1161/01.cir.29.5s4.iv-3 - DOI - PubMed
1. Ingles J, Burns C, Bagnall RD, Lam L, Yeates L, Sarina T, Puranik R, Briffa T, Atherton JJ, Driscoll T, et al. Nonfamilial hypertrophic cardiomyopathy: prevalence, natural history, and clinical implications. Circ Cardiovasc Genet. 2017;10:e001620. doi: 10.1161/CIRCGENETICS.116.001620 - DOI - PubMed
1. Maron BA, Wang RS, Carnethon MR, Rowin EJ, Loscalzo J, Maron BJ, Maron MS. What causes hypertrophic cardiomyopathy? Am J Cardiol. 2022;179:74–82. doi: 10.1016/j.amjcard.2022.06.017 - DOI - PMC - PubMed

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[1] Maron BJ. Clinical course and management of hypertrophic cardiomyopathy. N Engl J Med. 2018;379:655–666. doi: 10.1056/NEJMra1710575 - DOI - PubMed

[2] Maron BJ. Clinical course and management of hypertrophic cardiomyopathy. N Engl J Med. 2018;379:655–666. doi: 10.1056/NEJMra1710575 - DOI - PubMed

[3] Chou C, Chin MT. Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction. Int J Mol Sci. 2021;22:8933. doi: 10.3390/ijms22168933 - DOI - PMC - PubMed

[4] Chou C, Chin MT. Pathogenic mechanisms of hypertrophic cardiomyopathy beyond sarcomere dysfunction. Int J Mol Sci. 2021;22:8933. doi: 10.3390/ijms22168933 - DOI - PMC - PubMed

[5] Braunwald E, Lambrew CT, Rockoff SD, Ross J Jr, Morrow AG. Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation. 1964;30:3–119. doi: 10.1161/01.cir.29.5s4.iv-3 - DOI - PubMed

[6] Braunwald E, Lambrew CT, Rockoff SD, Ross J Jr, Morrow AG. Idiopathic hypertrophic subaortic stenosis. I. A description of the disease based upon an analysis of 64 patients. Circulation. 1964;30:3–119. doi: 10.1161/01.cir.29.5s4.iv-3 - DOI - PubMed

[7] Ingles J, Burns C, Bagnall RD, Lam L, Yeates L, Sarina T, Puranik R, Briffa T, Atherton JJ, Driscoll T, et al. Nonfamilial hypertrophic cardiomyopathy: prevalence, natural history, and clinical implications. Circ Cardiovasc Genet. 2017;10:e001620. doi: 10.1161/CIRCGENETICS.116.001620 - DOI - PubMed

[8] Ingles J, Burns C, Bagnall RD, Lam L, Yeates L, Sarina T, Puranik R, Briffa T, Atherton JJ, Driscoll T, et al. Nonfamilial hypertrophic cardiomyopathy: prevalence, natural history, and clinical implications. Circ Cardiovasc Genet. 2017;10:e001620. doi: 10.1161/CIRCGENETICS.116.001620 - DOI - PubMed

[9] Maron BA, Wang RS, Carnethon MR, Rowin EJ, Loscalzo J, Maron BJ, Maron MS. What causes hypertrophic cardiomyopathy? Am J Cardiol. 2022;179:74–82. doi: 10.1016/j.amjcard.2022.06.017 - DOI - PMC - PubMed

[10] Maron BA, Wang RS, Carnethon MR, Rowin EJ, Loscalzo J, Maron BJ, Maron MS. What causes hypertrophic cardiomyopathy? Am J Cardiol. 2022;179:74–82. doi: 10.1016/j.amjcard.2022.06.017 - DOI - PMC - PubMed

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Is Hypertrophic Cardiomyopathy Always a Familial and Inherited Disease?

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