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. 2023 Jun 10;23(1):157.
doi: 10.1186/s12893-023-02067-7.

Risk factors for intraoperative hemorrhage of Type I neurofibromatosis

Qianqian Gao #  1 , Siwei Qu #  1 , Ning Ma  1 , Weixin Wang  1 , Sen Chen  1 , Zhe Yang  2 , Yangqun Li  3
Affiliations

Risk factors for intraoperative hemorrhage of Type I neurofibromatosis

Qianqian Gao et al. BMC Surg. .

Abstract

Introduction: Neurofibromatosis (NF) is an inherited disease and a benign tumor originating from nerve sheath cells. Neurofibromatosis type I (NF1) is the most common type, and most cases are characterized by neurofibromas. Neurofibromas in NF1 are mainly treated by surgery. Our study explores the risk factors for intraoperative hemorrhage in Type I neurofibromatosis patients who underwent neurofibroma resection.

Methods: A cross-sectional comparison of the patients who had undergone resection of neurofibroma for NF1. Data regarding patient characteristics and data about operative outcomes were recorded. The definition of intraoperative hemorrhage group was the intraoperative blood loss greater than 200 ml.

Results: Of 94 eligible patients, 44 patients were in the hemorrhage group and 50 patients were in the non-hemorrhage group. Multiple logistic regression analysis demonstrated that the area of excision, classification, surgical site, primary surgical, and organ deformation were significant independent predictors of hemorrhage.

Conclusion: Early treatment can reduce the tumor cross-sectional area, avoid organ deformation, and reduce intraoperative blood loss. For plexiform neurofibroma or neurofibroma of the head and face, the amount of blood loss should be predicted correctly, and preoperative evaluation and blood preparation should be paid more attention to.

Keywords: Hemorrhage; Neurofibroma; Neurofibromatosis; Risk factors.

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Conflict of interest statement

The authors declare no competing interests.

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References

    1. Coy S, Rashid R, Stemmer-Rachamimov A, Santagata S. An update on the CNS manifestations of neurofibromatosis type 2. Acta Neuropathol. 2020;139(4):643–665. doi: 10.1007/s00401-019-02029-5. - DOI - PMC - PubMed
    1. Evans DG, Bowers NL, Tobi S, Hartley C, Wallace AJ, King AT, et al. Schwannomatosis: a genetic and epidemiological study. J Neurol Neurosurg Psychiatry. 2018;89(11):1215–1219. doi: 10.1136/jnnp-2018-318538. - DOI - PubMed
    1. Nix JS, Blakeley J, Rodriguez FJ. An update on the central nervous system manifestations of neurofibromatosis type 1. Acta Neuropathol. 2020;139(4):625–641. doi: 10.1007/s00401-019-02002-2. - DOI - PMC - PubMed
    1. Kresak JL, Walsh M. Neurofibromatosis: a review of NF1, NF2, and Schwannomatosis. J Pediatr Genet. 2016;5(2):98–104. doi: 10.1055/s-0036-1579766. - DOI - PMC - PubMed
    1. Wang W, Wei CJ, Cui XW, Li YH, Gu YH, Gu B, et al. Impacts of NF1 gene mutations and genetic modifiers in neurofibromatosis Type 1. Front Neurol. 2021;12:704639. doi: 10.3389/fneur.2021.704639. - DOI - PMC - PubMed