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Comment
. 2023 Jun 12;8(1):234.
doi: 10.1038/s41392-023-01507-3.

Harnessing the potential of spatial multiomics: a timely opportunity

Xuexin Li  1
Affiliations
Comment

Harnessing the potential of spatial multiomics: a timely opportunity

Xuexin Li. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no competing interests.

Figures

Fig. 1
Fig. 1
Representative Technologies and Publications in Spatial Multiomics: A Revisit of the Last Five Years. The line graph illustrates the number of publications on single-cell spatial multi-omics over the past five years, categorized into five groups based on relevant keywords. Meanwhile, the accompanying bar plot displays the publication count for each category per year, sourced from Pubmed. The figure also showcases representative technologies and important procedures, with the three categories based on the omics combination. For single-cell spatial proteomics and transcriptomics, the technologies presented include spatial CITE-seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing), DBiT (Deterministic barcoding in tissue for spatial omics sequencing), SM-OMICS (Spatial Multi-Omics), and GEOMx (GeoMx DSP). For single-cell spatial epigenomics and transcriptomics, the figure introduces spatial CUT&TAG/ATAC RNAseq (Cleavage Under Targets & Tagmentation/Assay for Transposase-Accessible Chromatin using sequencing) and spatial DNA seqFISH (DNA sequential Fluorescence In Situ Hybridization) as representative technologies. Lastly, for single-cell spatial epigenomics/genomics and transcriptomics, the figure showcases spatial DNA-MERFISH (DNA-Multiplexed error-robust fluorescence in situ hybridization) and Oligo FISSEQ (Oligo fluorescent in situ sequencing) as representative technologies. The figure also includes several abbreviations, such as FFPE for “formalin-fixed paraffin-embedded”, H&E for “Hematoxylin and eosin stain”, RT for “reverse transcription”, LIT for “ligation-based interrogation of targets”, SIT for “sequencing by synthesis to effect synthesis-based interrogation of targets”, and HIT for “hybridization-based interrogation of targets”. Figure created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Spatial epigenome-transcriptome co-profiling of mammalian tissues.
    Zhang D, Deng Y, Kukanja P, Agirre E, Bartosovic M, Dong M, Ma C, Ma S, Su G, Bao S, Liu Y, Xiao Y, Rosoklija GB, Dwork AJ, Mann JJ, Leong KW, Boldrini M, Wang L, Haeussler M, Raphael BJ, Kluger Y, Castelo-Branco G, Fan R. Zhang D, et al. Nature. 2023 Apr;616(7955):113-122. doi: 10.1038/s41586-023-05795-1. Epub 2023 Mar 15. Nature. 2023. PMID: 36922587 Free PMC article.

References

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Publication types