Treatment de-intensification for low-risk biochemical recurrence after radical prostatectomy: rational or risky?

Matthew J Roberts^{1

2}, George Hruby^{3

4}, Andrew Kneebone^{3

4}, Jarad M Martin^{5

6}, Scott G Williams^{7

8

9}, Mark Frydenberg^{10

11}, Declan G Murphy^{7

8

12}, Ben Namdarian¹³, John W Yaxley^{1

2}, Michael S Hofman^{7

8

14}, Ian D Davis^{15

16}, Louise Emmett^{17

18}

Affiliations

¹ Department of Urology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
² Faculty of Medicine, University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
³ Department of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
⁴ Genesis Cancer Care, Sydney, New South Wales, Australia.
⁵ Department of Radiation Oncology, Calvary Mater Newcastle, Waratah, New South Wales, Australia.
⁶ Genesis Care, Maitland, Metford, New South Wales, Australia.
⁷ Sir Peter MacCallum Department of Oncology, Melbourne University, Parkville, Victoria, Australia.
⁸ Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁹ Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁰ Department of Surgery, Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
¹¹ Cabrini Research, Cabrini Health, Melbourne, Victoria, Australia.
¹² Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹³ St Vincent's Hospital, Darlinghurst, Sydney, New South Wales, Australia.
¹⁴ Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Victoria, Melbourne, Australia.
¹⁵ Eastern Health Clinical School, Monash University, Victoria, Melbourne, Australia.
¹⁶ Department of Cancer Services, Eastern Health, Melbourne, Victoria, Australia.
¹⁷ Department of Theranostics and Nuclear Medicine, St. Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.
¹⁸ Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

PMID: 37303121
DOI: 10.1111/bju.16086

Treatment de-intensification for low-risk biochemical recurrence after radical prostatectomy: rational or risky?

Matthew J Roberts et al. BJU Int. 2023 Aug.

. 2023 Aug;132(2):146-148.

doi: 10.1111/bju.16086. Epub 2023 Jun 11.

Authors

Affiliations

¹ Department of Urology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
² Faculty of Medicine, University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
³ Department of Radiation Oncology, Royal North Shore Hospital, Sydney, New South Wales, Australia.
⁴ Genesis Cancer Care, Sydney, New South Wales, Australia.
⁵ Department of Radiation Oncology, Calvary Mater Newcastle, Waratah, New South Wales, Australia.
⁶ Genesis Care, Maitland, Metford, New South Wales, Australia.
⁷ Sir Peter MacCallum Department of Oncology, Melbourne University, Parkville, Victoria, Australia.
⁸ Prostate Cancer Theranostics and Imaging Centre of Excellence, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
⁹ Division of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹⁰ Department of Surgery, Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
¹¹ Cabrini Research, Cabrini Health, Melbourne, Victoria, Australia.
¹² Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
¹³ St Vincent's Hospital, Darlinghurst, Sydney, New South Wales, Australia.
¹⁴ Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Victoria, Melbourne, Australia.
¹⁵ Eastern Health Clinical School, Monash University, Victoria, Melbourne, Australia.
¹⁶ Department of Cancer Services, Eastern Health, Melbourne, Victoria, Australia.
¹⁷ Department of Theranostics and Nuclear Medicine, St. Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.
¹⁸ Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.

PMID: 37303121
DOI: 10.1111/bju.16086

No abstract available

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References

1. Mottet N, Bellmunt J, Briers E et al. EAU - ESTRO - ESUR - SIOG Guidelines on Prostate Cancer. Arnhem, The Netherlands: EAU Guidelines Office, 2022
1. Adam M, Tennstedt P, Lanwehr D et al. Functional outcomes and quality of life after radical prostatectomy only versus a combination of prostatectomy with radiation and hormonal therapy. Eur Urol 2017; 71: 330-6
1. Fendler WP, Calais J, Eiber M et al. Assessment of 68Ga-PSMA-11 PET accuracy in localizing recurrent prostate cancer: A prospective single-arm clinical trial. JAMA Oncol 2019; 5: 856-63
1. Emmett L, Tang R, Nandurkar R et al. 3-year freedom from progression after (68)Ga-PSMA PET/CT-triaged Management in men with biochemical recurrence after radical prostatectomy: Results of a prospective multicenter trial. J Nucl Med 2020; 61: 866-72
1. Roberts MJ, Chatfield MD, Hruby G et al. Event-free survival after radical prostatectomy according to prostate-specific membrane antigen-positron emission tomography and European Association of Urology biochemical recurrence risk groups. BJU Int 2022; 130(Suppl 3): 32-9

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Treatment de-intensification for low-risk biochemical recurrence after radical prostatectomy: rational or risky?

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Treatment de-intensification for low-risk biochemical recurrence after radical prostatectomy: rational or risky?

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