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. 2022 Oct-Dec;48(4):393-397.
doi: 10.12865/CHSJ.48.04.05. Epub 2022 Dec 31.

Snail Immunoexpression in Endometrioid Endometrial Carcinomas

Mirela Marinela Florescu  1 , Oana Iulia Crețu  1 , Andrei Muraru  1 , Dan Nicolae Florescu  2 , Cristiana Eugenia Simionescu  1
Affiliations

Snail Immunoexpression in Endometrioid Endometrial Carcinomas

Mirela Marinela Florescu et al. Curr Health Sci J. 2022 Oct-Dec.

Abstract

Endometrial carcinoma is one of the most prevalent cancers affecting women with epidemiological placing it as the sixth most common cancer in women. One of the factors implicated in EMT (epithelial-mesenchymal transition), Snail is regarded as having a pivotal role. We selected a number of 30 endometrial carcinomas, in a 2-year period (2020-2022). Snail immunoexpression was identified in the tumor cells for 70% of the endometroid carcinoma cases studied. Tumor cells showed both nuclear and cytoplasmic expression but only nuclear signals were quantified. The average percent of marked tumor cells was 38.6±24.9, corresponding to well differentiated carcinomas. Our analysis also showed a significant association between higher tumor grade and snail expression (p=0.000). Alteration of the epithelial-mesenchymal phenotype in endometrial carcinomas by Snail overexpression in high-grade and advanced-stage lesions constitutes mechanisms involved in the process of tumor progression.

Keywords: Endometroid endometrial carcinoma; Snail; epithelial-mesenchymal transition; immunohistochemistry.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Endometrioid endometrial carcinoma, Snail (A, B, C) immunostaining, 20x; (A,) WD-well differentiated, (B) MD-moderate differentiated and (C) PD-poorly differentiated, (D)ANOVA graphic representation of Snail statistical differences regarding the tumor differentiation degree.
See this image and copyright information in PMC

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