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. 2022 Oct-Dec;48(4):413-417.
doi: 10.12865/CHSJ.48.04.08. Epub 2022 Dec 31.

Ezrin Immunoexpression in Prostate Adenocarcinomas

Tudor Cristian Timotei Popescu  1 , Alex Emilian Stepan  2 , Mirela Marinela Florescu  2 , Cristiana Eugenia Simionescu  2
Affiliations

Ezrin Immunoexpression in Prostate Adenocarcinomas

Tudor Cristian Timotei Popescu et al. Curr Health Sci J. 2022 Oct-Dec.

Abstract

Ezrin is a component of cell surface structures, the most important member of the Ezrin/radixin/moesin family. In this study, we aimed to evaluate the expression of ezrin in 50 cases of prostate carcinoma (PA) in relation to the ISUP (International Society of Urological Pathology) groups. Ezrin expression analysis was identified in 78% of the PA cases investigated, with predominantly cytoplasmic staining pattern and variable intensity. Overall, we observed an increase in the intensity of the immunostaining progressively with the decrease in cell differentiation. Statistical analysis indicated the predominance of high FSS in the ISUP 4-5 groups and low FSS in the ISUP 1-2 groups, aspects that were statistically significant. Ezrin was expressed in the majority of PAs analyzed and its expression was associated with ISUP grades, an aspect that suggests involvement in PA progression.

Keywords: ISUP groups; Prostate adenocarcinoma; ezrin.

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Conflict of interest statement

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
Ezrin immunoexpression in PA, x400: A. ISUP 1 (3+3) group; B. ISUP 2 (3+4) group; C. ISUP 3 (4+3) group; D. ISUP 4 (3+5) group; E. ISUP 5 (5+4) group; F. Distribution of cases in relation to Ezrin FSS and ISUP grading groups.
See this image and copyright information in PMC

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