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Review
. 2023 May 25:14:1118342.
doi: 10.3389/fphys.2023.1118342. eCollection 2023.

SLC26 family: a new insight for kidney stone disease

Jialin Li  1   2 , Sigen Huang  1   2 , Shengyin Liu  1   2 , Xinzhi Liao  1   2 , Sheng Yan  1   2 , Quanliang Liu  2
Affiliations
Review

SLC26 family: a new insight for kidney stone disease

Jialin Li et al. Front Physiol. .

Abstract

The solute-linked carrier 26 (SLC26) protein family is comprised of multifunctional transporters of substrates that include oxalate, sulphate, and chloride. Disorders of oxalate homeostasis cause hyperoxalemia and hyperoxaluria, leading to urinary calcium oxalate precipitation and urolithogenesis. SLC26 proteins are aberrantly expressed during kidney stone formation, and consequently may present therapeutic targets. SLC26 protein inhibitors are in preclinical development. In this review, we integrate the findings of recent reports with clinical data to highlight the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discuss limitations of current studies and potential directions for future research.

Keywords: SLC26; hyperoxaluria; kidney stone; oxalate; oxalate metabolism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Anatomic distribution of SLC26 protein expressions.
FIGURE 2
FIGURE 2
SLC26 protein structure. SLC26 including an N-terminal structural domain, a segment consisting of 10–14 transmembrane segments (the red square indicates differences in hydrophobic span that may exist between members), a C-terminal sulfate transporter and anti-sigma factor antagonist structural domain (STAS), and a PDZ structural domain.
See this image and copyright information in PMC

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