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Case Reports
. 2023 May 31:44:101878.
doi: 10.1016/j.rmcr.2023.101878. eCollection 2023.

Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report

Yoshio Nakano  1 , Daisuke Sekinada  1 , Gen Masuda  1 , Chihiro Nishio  1 , Koji Nishida  1 , Norio Okamoto  1 , Iwao Gohma  1 , Yoshiki Esa  2
Affiliations
Case Reports

Clarithromycin-induced eosinophilic granulomatosis with polyangiitis: A case report

Yoshio Nakano et al. Respir Med Case Rep. .

Abstract

A 75-year-old man presented to our hospital with chronic sinusitis, bronchiectasis, and chronic lower respiratory tract infections. He began taking erythromycin in August, X-2. The chronic lower respiratory tract infection gradually worsened, and clarithromycin was started on May 11, X. He became aware of fever and numbness in his lower legs on June 4, X. The sign occurred soon after oral clarithromycin and blood tests showed an elevated eosinophil count and C-reactive protein (CRP) levels, positive MPO-ANCA antibodies, and positive for drug-induced lymphocyte stimulation test (DLST); we diagnosed eosinophilic granulomatosis with polyangiitis (EGPA) associated with clarithromycin administration.

Keywords: Clarithromycin; Drug-induced lymphocyte stimulation test; Eosinophilic granulomatosis with polyangiitis; MPO-ANCA antibodies.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
A: August, X-2, chest CT scan showed lobular central granular shadows and bilateral bronchial wall thickening in the lower lobes. B: July, X-1, sinus CT showed soft shadows in both maxillary sinuses and anterior ethmoidal sinuses, raising the suspicion of chronic sinusitis. C: February, X, bilateral granular shadows worsened slightly on CT imaging. CT, computed tomography.
See this image and copyright information in PMC

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