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Case Reports
. 2023 Aug:70:103133.
doi: 10.1016/j.scr.2023.103133. Epub 2023 Jun 7.

Generation of induced pluripotent stem cell line (RCMGi009-A) from urine cells of patient with fibrodysplasia ossificans progressiva

Ekaterina Kondrateva  1 , Olga Grigorieva  2 , Elizaveta Kurshakova  2 , Irina Panchuk  2 , Victoria Pozhitnova  2 , Ekaterina Voronina  2 , Vyacheslav Tabakov  2 , Maria Orlova  2 , Alexander Lavrov  2 , Svetlana Smirnikhina  2 , Sergey Kutsev  2
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Free article
Case Reports

Generation of induced pluripotent stem cell line (RCMGi009-A) from urine cells of patient with fibrodysplasia ossificans progressiva

Ekaterina Kondrateva et al. Stem Cell Res. 2023 Aug.
Free article

Abstract

Urine cells obtained from a 14-year-old man with genetically proven (ACVR1: c.6176G > A) and clinically manifested fibrodysplasia ossificans progressiva were successfully transformed into induced pluripotent stem cells by using Sendai virus-based reprogramming vectors including the four Yamanaka factors such as OCT3/4, SOX2, KLF4, and c-MYC. These iPSCs expressed pluripotency markers, exhibited the potential to differentiate into three germ layers in spontaneous differentiation assay and had a normal karyotype. The iPSC line may provide a model for development of a personalized treatment including genome editing and drug screening, may be used for disease modelling, cell differentiation and pharmacological investigations. .

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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