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Case Reports
. 2023 May 11;15(5):e38908.
doi: 10.7759/cureus.38908. eCollection 2023 May.

Metformin-Induced Acute Hepatitis

Arooj Mian  1 , Baha Aldeen Bani Fawwaz  1 , Gurdeep Singh  1 , Aimen Farooq  1 , Ayman Koteish  2
Affiliations
Case Reports

Metformin-Induced Acute Hepatitis

Arooj Mian et al. Cureus. .

Abstract

Metformin is considered an initial oral pharmacotherapy of choice for treating hyperglycemia in type 2 diabetes mellitus (T2DM). Although safe in the vast majority of the population, rare side effects will come to light as the prevalence of T2DM continues to rise. We present a rare case of metformin-induced hepatotoxicity and possibly the first reported case of dose-dependent metformin-induced hepatotoxicity. This case report aims to make clinicians aware of this infrequent yet significant adverse reaction that can arise with metformin therapy.

Keywords: diabetes; drug-induced liver injury (dili); hepatitis; hepatotoxicity; idiosyncratic liver injury; liver disease; metformin-induced acute hepatitis; metformin-induced hepatotoxicity; metformin-induced lactic acidosis; s: hepatotoxicity.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Dose-dependent metformin-induced hepatotoxicity.
AST: Aspartate transaminase; ALT: Alanine aminotransferase.
See this image and copyright information in PMC

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