Clinical and Molecular Features of Patients With Leptin and Leptin Receptor Deficiency: Lessons of 25 Years of Research

Jesús Argente^{1

2

3}, Manuel Tena-Sempere^{2

4

5}

Affiliations

¹ Department of Pediatrics & Pediatric Endocrinology, Universidad Autónoma de Madrid; University Hospital Niño Jesús, Instituto de Investigación Sanitaria La Princesa, 28009 Madrid, Spain.
² CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain.
³ IMDEA Food Institute, 28049 Madrid, Spain.
⁴ Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain.
⁵ Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.

Editorial

Jesús Argente et al. J Clin Endocrinol Metab. 2023.

. 2023 Dec 21;109(1):e424-e425.

doi: 10.1210/clinem/dgad353.

Jesús Argente^{1

2

3}, Manuel Tena-Sempere^{2

4

5}

¹ Department of Pediatrics & Pediatric Endocrinology, Universidad Autónoma de Madrid; University Hospital Niño Jesús, Instituto de Investigación Sanitaria La Princesa, 28009 Madrid, Spain.
² CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain.
³ IMDEA Food Institute, 28049 Madrid, Spain.
⁴ Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain.
⁵ Department of Cell Biology, Physiology and Immunology, University of Córdoba, 14004 Córdoba, Spain.

No abstract available

Keywords: comorbidities; gene variants; leptin; leptin receptor; monogenic obesity; treatment.

Comment on

A National Multicenter Study of Leptin and Leptin Receptor Deficiency and Systematic Review.
Besci Ö, Fırat SN, Özen S, Çetinkaya S, Akın L, Kör Y, Pekkolay Z, Özalkak Ş, Özsu E, Erdeve ŞS, Poyrazoğlu Ş, Berberoğlu M, Aydın M, Omma T, Akıncı B, Demir K, Oral EA. Besci Ö, et al. J Clin Endocrinol Metab. 2023 Aug 18;108(9):2371-2388. doi: 10.1210/clinem/dgad099. J Clin Endocrinol Metab. 2023. PMID: 36825860