Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 23;25(24):4445-4450.
doi: 10.1021/acs.orglett.3c01366. Epub 2023 Jun 13.

Groebke-Blackburn-Bienaymé Reaction for DNA-Encoded Library Technology

Yujin An  1 , Juyeon Lee  1 , Hyewon Seo  2 , Seri Bae  2 , Jihee Kang  2 , Jieon Lee  2 , Jinwoo Kim  3 , Myung Hee Nam  3 , Minsoo Song  2 , Gil Tae Hwang  1
Affiliations

Groebke-Blackburn-Bienaymé Reaction for DNA-Encoded Library Technology

Yujin An et al. Org Lett. .

Abstract

This study presents a DNA-compatible synthesis of diverse 5-arylimidazo[1,2-a]pyridin-3-amine derivatives using the Suzuki-Miyaura reaction, followed by a Groebke-Blackburn-Bienaymé (GBB) reaction. The GBB reaction demonstrates a wide substrate scope, mild one-pot reaction conditions, and compatibility with subsequent enzymatic ligation, highlighting its potential in DNA-encoded library technology.

PubMed Disclaimer

Publication types