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Review
. 2023 Aug:164:114996.
doi: 10.1016/j.biopha.2023.114996. Epub 2023 Jun 11.

Current research status of anti-cancer peptides: Mechanism of action, production, and clinical applications

Raj Kumar Chinnadurai  1 , Nazam Khan  2 , Gautam Kumar Meghwanshi  3 , Saravanaraman Ponne  4 , Maryam Althobiti  5 , Rajender Kumar  6
Affiliations
Free article
Review

Current research status of anti-cancer peptides: Mechanism of action, production, and clinical applications

Raj Kumar Chinnadurai et al. Biomed Pharmacother. 2023 Aug.
Free article

Abstract

The escalating rate of cancer cases, together with treatment deficiencies and long-term side effects of currently used cancer drugs, has made this disease a global burden of the 21st century. The number of breast and lung cancer patients has sharply increased worldwide in the last few years. Presently, surgical treatment, radiotherapy, chemotherapy, and immunotherapy strategies are used to cure cancer, which cause severe side effects, toxicities, and drug resistance. In recent years, anti-cancer peptides have become an eminent therapeutic strategy for cancer treatment due to their high specificity and fewer side effects and toxicity. This review presents an updated overview of different anti-cancer peptides, their mechanisms of action and current production strategies employed for their manufacture. In addition, approved and under clinical trials anti-cancer peptides and their applications have been discussed. This review provides updated information on therapeutic anti-cancer peptides that hold great promise for cancer treatment in the near future.

Keywords: Anti-cancer; Cell apoptosis; Clinical application; Mechanism; Metastatic; Peptide production.

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Conflict of interest statement

Declaration of Competing Interest It is to certify that all authors have seen and approved the manuscript being submitted to Biomedicine & Pharmacotherapy. We declare that the article is not under consideration for publication, and will not be submitted for publication elsewhere, in whole or in part, while under consideration for publication in Biomedicine & Pharmacotherapy. On behalf of all Co-Authors, the corresponding Author shall bear full responsibility for the submission. We have no conflict of interest to declare.

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