Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986;22(3):169-75.
doi: 10.1007/BF00200028.

Site-related differences in the localization of the monoclonal antibody OX7 in SL2 and SL1 lymphomas

H Sands, P L Jones, W P Neacy, S A Shah, B M Gallagher

Site-related differences in the localization of the monoclonal antibody OX7 in SL2 and SL1 lymphomas

H Sands et al. Cancer Immunol Immunother. 1986.

Abstract

The uptake of a monoclonal antibody (OX7) by murine lymphomas (SL1, SL2) growing in two sites in the mouse were compared. SL2 tumors grown in the subrenal site showed greater specific antibody uptake than did the same tumor grown in the subcutaneous site. Major differences in membrane bound antibody, in vitro antibody binding patterns, and gamma scintillation camera imaging were also observed between the two sites. These differences may be due to the greater blood flow measured in tumors growing in the subrenal capsule than those growing at the subcutaneous site. The differences observed in antibody uptake of the same tumor growing in two different sites raises questions concerning the choice of animal model systems that can be used to predict clinical utility.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Accolla RS, Carrel S, Mach J-P. Monoclonal antibodies specific for carcinoembroyonic antigen and produced by two hybrid cell lines. Proc Natl Acad Sci USA. 1980;77:563–566. - PMC - PubMed
    1. Ackerman NB, Hechmer PA. Comparison of vascular permeability of tumors and liver host tissues. Bibl Anat. 1977;15:304–306. - PubMed
    1. Ballou B, Levine G, Hakala RJ, Solter D. Tumor location detected with radioactively labelled monoclonal antibodies and external scintigraphy. Science. 1979;206:844–847. - PubMed
    1. Bogden A, Kelton D, Cobb W, Esber H (1978) A rapid screening method for testing chemotherapeutic agents against human xenografts, In: Houchens DP, Ovejera AA, Fischer Gustav (eds) Proceedings of Symposium on the Use of Athymic (Nude) Mice in Cancer Research. New York, pp 231–250
    1. Colcher D, Keenan AM, Larson SM, Schlom J. Prolonged binding of a radiolabeled monoclonal antibody (B72.3) used in the in situ radioimmunodetection of human colon carcinoma xenografts. Cancer Res. 1981;44:5744–5751. - PubMed

LinkOut - more resources